SORL1 rs1699102 polymorphism modulates age-related cognitive decline and gray matter volume reduction in non-demented individuals.
SORL1 rs1699102 polymorphism modulates age-related cognitive decline and gray matter volume reduction in non-demented individuals.
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SORL1 rs1699102 多态性调节非痴呆个体中与年龄相关的认知能力下降和灰质体积减少。
DOI：
10.1111/ene.13182
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发表时间：
2017-01
影响因子：
5.1
通讯作者：
Zhang Z
中科院分区：
文献类型：
--
作者：
Li H;Lv C;Yang C;Wei D;Chen K;Li S;Zhang Z
SORL1 rs1699102与晚发性阿尔茨海默病（AD）的风险相关。然而，该SNP在正常衰老过程中对认知和大脑结构的影响尚不清楚。本研究旨在探讨rs1699102多态性对中国汉族人群年龄相关认知能力下降和皮质灰质减少的影响。780名非痴呆成年人完成了一系列神经心理学测试。89名受试者的高分辨率t1加权结构磁共振成像（MRI）数据也使用西门子Trio 3.0特斯拉扫描仪收集。与CC基因型相比，T等位基因携带者在情景记忆和加工速度测试中表现出加速的年龄相关变化。在右颞中极与年龄相关的灰质体积（GMV）减少中也观察到类似的模式。该区域的GMV与情景记忆得分呈显著正相关。SORL1基因rs1699102多态性被发现与老年人年龄相关的认知能力下降和右颞中极GMV降低有关。这些发现阐明了SORL1变异如何塑造神经系统以调节与年龄相关的认知衰退，并支持SORL1可能代表晚发性AD候选基因的假设。
SORL1 rs1699102 is associated with the risk of late-onset Alzheimer's disease (AD). However, the effects of this SNP on cognition and brain structure during normal aging are unclear. This study aims to examine the effects of the rs1699102 polymorphism on age-related cognitive decline and cortical gray matter reduction in Chinese Han population. 780 non-demented adults completed a battery of neuropsychological tests. High-resolution T1-weighted structural magnetic resonance imaging (MRI) data from 89 of these subjects were also collected using a Siemens Trio 3.0 Tesla scanner. The T allele carriers displayed an accelerated age-related change in episodic memory and processing speed tests relative to the CC genotype. A similar pattern was observed in the age-related gray matter volume (GMV) reduction of the right middle temporal pole. The GMV in this region was significantly positively correlated with the episodic memory scores. The SORL1 gene rs1699102 polymorphism has been found to be associated with age-related cognitive decline and GMV reduction of the right middle temporal pole in older adults. These findings elucidate how the SORL1 variants shape the neural system to modulate age-related cognitive decline and support the hypothesis that SORL1 may represent a candidate gene for late-onset AD.
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影响因子：
9.9
作者：
ISHIAI, S;SUGISHITA, M;WATABIKI, S
通讯作者：
WATABIKI, S
影响因子：
2.5
作者：
Lee, Joseph. H.;Chulikavit, Maruit;Schupf, Nicole
通讯作者：
Schupf, Nicole
影响因子：
4.2
作者：
Reynolds CA;Zavala C;Gatz M;Vie L;Johansson B;Malmberg B;Ingelsson E;Prince JA;Pedersen NL
通讯作者：
Pedersen NL
影响因子：
17.7
作者：
Bralten, Janita;Arias-Vasquez, Alejandro;Franke, Barbara
通讯作者：
Franke, Barbara
影响因子：
14.5
作者：
Nakamura, K;Kawashima, R;Zilles, K
通讯作者：
Zilles, K