Magnetic steering of a distributed ferrofluid spot towards a deep target with minimal spreading

Magnetic steering of a distributed ferrofluid spot towards a deep target with minimal spreading
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以最小的扩散将分布式铁磁流体点磁转向至深层目标

DOI:
10.1109/cdc.2011.6160737
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发表时间:
2011
期刊:
IEEE Conference on Decision and Control and European Control Conference
影响因子:
--
通讯作者:
B. Shapiro
B. Shapiro
中科院分区:
--
文献类型:
--
作者:
Arash Komaee;B. Shapiro

文献摘要

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在磁性药物靶向中,药物被附着在磁性纳米颗粒上,然后使用外部磁体将治疗集中在实体肿瘤上,因此需要更好地控制和聚焦粒子(磁流体)的分布到深层靶点。这篇论文考虑了下一个关键问题:如何以最小的扩散将单个磁流体光斑移动到深部目标。这个问题很有挑战性,因为外加的磁力有一种自然的趋势来拉伸磁流体斑点。设计了一种控制策略,并通过仿真进行了验证,以最优地控制多个电磁体,以最小的扩展将单个磁流体光点从磁区边缘移动到深中心目标。
In magnetic drug targeting, where drugs are attached to magnetic nanoparticles and external magnets are then used to focus the therapy to, for example, solid tumors, there is a need to better control and focus the distribution of particles (the ferrofluid) to deep targets. This paper considers a key next question: how to move a single spot of ferrofluid to a deep target with minimal spreading. The problem is challenging since the applied magnetic forces have a natural tendency to stretch the ferrofluid spot. A control policy is designed and verified by simulations to optimally control multiple electromagnets in concert to move a single spot of ferrofluid from the edge of a domain to a deep central target with minimal spreading.
DOI: 10.1021/bc8004649
发表时间: 2009-02
影响因子: 4.7
作者:
Devaraj NK;Keliher EJ;Thurber GM;Nahrendorf M;Weissleder R
通讯作者: Weissleder R
DOI: 10.2217/nnm.10.104
发表时间: 2010-11
期刊: Nanomedicine (London, England)
影响因子: --
作者:
Nacev A;Beni C;Bruno O;Shapiro B
通讯作者: Shapiro B
DOI: 10.1016/j.jmmm.2009.02.094
发表时间: 2009-05-01
影响因子: 2.7
作者:
Shapiro B
通讯作者: Shapiro B