Towards dynamic control of magnetic fields to focus magnetic carriers to targets deep inside the body.

Towards dynamic control of magnetic fields to focus magnetic carriers to targets deep inside the body.
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DOI:
10.1016/j.jmmm.2009.02.094
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发表时间:
2009-05-01
影响因子:
2.7
通讯作者:
Shapiro B
Shapiro B
中科院分区:
材料科学3区
文献类型:
--
作者:
Shapiro B

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磁性药物递送具有将治疗靶向到身体特定区域的潜力,从而提高疗效并减少治疗癌症、中风、感染和其他疾病的副作用。使用吸引磁性药物载体的固定外部磁体,这种治疗仅限于浅目标(使用最强的、仍然安全的、实用的磁场,低于皮肤深度<5 cm)。我们认为动态磁致动和目前的初步结果表明,它是可能的,以不同的磁铁对其他集中载体之间的平均。然后简要说明体内深度靶向的许多剩余任务。
Magnetic drug delivery has the potential to target therapy to specific regions in the body, improving efficacy and reducing side effects for treatment of cancer, stroke, infection, and other diseases. Using stationary external magnets, which attract the magnetic drug carriers, this treatment is limited to shallow targets (<5 cm below skin depth using the strongest possible, still safe, practical magnetic fields). We consider dynamic magnetic actuation and present initial results that show it is possible to vary magnets one against the other to focus carriers between them on average. The many remaining tasks for deep targeting in-vivo are then briefly noted.
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