The threshold level of urinary cadmium associated with increased urinary excretion of retinol-binding protein and beta 2-microglobulin: a re-assessment in a large cohort of nickel-cadmium battery workers.
The threshold level of urinary cadmium associated with increased urinary excretion of retinol-binding protein and beta 2-microglobulin: a re-assessment in a large cohort of nickel-cadmium battery workers.
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DOI：
10.1136/oem.2009.054122
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发表时间：
2011-04
影响因子：
4.9
通讯作者：
Bernard A
中科院分区：
文献类型：
--
作者：
Chaumont A;De Winter F;Dumont X;Haufroid V;Bernard A
在不受蛋白质降解、利尿和慢性吸烟对肾脏影响影响的基础上，评估尿镉（CdU）对肾功能障碍的阈值。我们研究了599名工人（451名男性，平均年龄45.4岁），他们在四个镍镉电池厂工作了平均18.8年。通过多元回归调整协变量后，以CdU<1 μg/g肌酐的工人为参照，通过logistic回归和基准剂量分析评估视黄醇结合蛋白（RBPU）和b2-微球蛋白（b2-mU）浓度升高的CdU阈值。尿蛋白与CdU （μg/g肌酐）的关系受性别、年龄、利尿、吸烟等因素的影响。当考虑所有工人时，RBPU和b2-mU异常的几率分别从CdU的6-10和bb10显著增加。RBPU和b2-mU异常背景患病率超过5%的基准剂量（BMD5）和基准剂量下限（BMDL5）估计为5.1/3.0和9.6/5.9。当排除曾经吸烟的工人时，RBPU和b2-mU异常的几率仅在CdU为10的工人中增加（分别为OR， 21.8, 95% CI, 6.4-74.4和OR， 15.1, 95% CI, 3.6-63.1）。在从不吸烟者中，CdU的BMD5/BMDL5估计为12.6/6.6和12.2/5.5，而在曾经吸烟者中，它们分别为6.2/4.9和4.3/3.5。基于未被吸烟扭曲的关联和校正协变量，职业性接触镉所致低分子蛋白尿的CdU BMDL5可以可靠地估计在5.5 ~ 6.6 μg/g肌酐之间。
To evaluate the threshold value of urinary cadmium (CdU) for renal dysfunction on the basis of relationships unconfounded by protein degradation, diuresis and the renal effects associated with chronic smoking. We studied 599 workers (451 men, mean age 45.4 years) who were employed in four nickel-cadmium battery plants for 18.8 years on average. After adjustment for covariates by multiple regression, the CdU threshold values for increased concentrations of retinol-binding protein (RBPU) and b2-microglobulin (b2-mU) were assessed by logistic regression and benchmark dose analyses using as referents workers with CdU<1 μg/g creatinine. Relationships between urinary proteins and CdU (μg/g creatinine) were influenced by sex, age, diuresis and especially smoking. When considering all workers, odds for abnormal RBPU and b2-mU were significantly increased from CdU of 6-10 and >10, respectively. The benchmark dose (BMD5) and the benchmark dose lower limit (BMDL5) for a 5% excess in the background prevalence of abnormal RBPU and b2-mU were estimated at 5.1/3.0 and 9.6/5.9. When excluding ever smokers, odds for abnormal RBPU and b2-mU were both increased only among workers with CdU>10 (OR, 21.8, 95% CI, 6.4-74.4 and OR, 15.1, 95% CI, 3.6-63.1, respectively). In never smokers, these BMD5/BMDL5 of CdU were estimated at 12.6/6.6 and 12.2/5.5 while in ever smokers they were 6.2/4.9 and 4.3/3.5. On the basis of associations undistorted by smoking and adjusted for covariates, the BMDL5 of CdU for low-molecular-weight proteinuria induced by occupational exposure to Cd can be reliably estimated between 5.5 and 6.6 μg/g creatinine.
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影响因子：
3.8
作者：
BERNARD, AM;LAUWERYS, RR
通讯作者：
LAUWERYS, RR
影响因子：
10.4
作者：
NORDBERG, M
通讯作者：
NORDBERG, M
影响因子：
13.2
作者：
Briganti, EM;Branley, P;Atkins, RC
通讯作者：
Atkins, RC
DOI：
10.1111/j.1365-2362.1979.tb01662.x
发表时间：
1979-01-01
影响因子：
5.5
作者：
BERNARD, A;BUCHET, JP;LAUWERYS, R
通讯作者：
LAUWERYS, R
影响因子：
10.4
作者：
de Burbure C;Buchet JP;Leroyer A;Nisse C;Haguenoer JM;Mutti A;Smerhovsky Z;Cikrt M;Trzcinka-Ochocka M;Razniewska G;Jakubowski M;Bernard A
通讯作者：
Bernard A