Structure and correlates of cognitive aging in a narrow age cohort.
Structure and correlates of cognitive aging in a narrow age cohort.
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DOI：
10.1037/a0036187
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发表时间：
2014-06
影响因子：
3.7
通讯作者：
Deary IJ
中科院分区：
文献类型：
--
作者：
Tucker-Drob EM;Briley DA;Starr JM;Deary IJ
认知功能的多个领域发生与衰老相关的变化。越来越多的研究表明，与年龄相关的认知变化在各个领域之间存在中度到强烈的相关性，而不是代表统计上独立的现象。然而，以前的研究通常是在6年或更长时间的纵向时间滞后的年龄异质性样本中进行的，并且没有考虑结果是否对一组全面的对照具有鲁棒性。利用1936年洛锡安出生队列的3年纵向数据，我们采用纵向窄年龄队列方法来研究70至73岁年龄段的跨领域认知变化相互关系。我们拟合多变量潜在差异得分模型的因素代表视觉空间能力，处理速度，记忆力和结晶能力。变化是适度相关的，与一般因素的变化占47%的变化跨域的方差。在控制了一整套人口统计学、身体和医学因素（包括教育程度、儿童智力、身体功能、APOE基因型、吸烟状况、高血压诊断、心血管疾病诊断和糖尿病诊断）后，变化的相互关系仍接近于完全强度。因此，与年龄相关的认知变化的积极多方面是非常稳健的，因为它可以在一个狭窄的年龄队列中检测到，在一个相对较短的纵向时间内，即使在控制了许多潜在的混杂因素后仍然存在。
Aging-related changes occur for multiple domains of cognitive functioning. An accumulating body of research indicates that, rather than representing statistically independent phenomena, aging-related cognitive changes are moderately to strongly correlated across domains. However, previous studies have typically been conducted in age-heterogeneous samples over longitudinal time lags of 6 or more years, and have failed to consider whether results are robust to a comprehensive set of controls. Capitalizing on 3-year longitudinal data from the Lothian Birth Cohort of 1936, we took a longitudinal narrow age cohort approach to examine cross-domain cognitive change interrelations from ages 70 to 73 years. We fit multivariate latent difference score models to factors representing visuospatial ability, processing speed, memory, and crystallized ability. Changes were moderately interrelated, with a general factor of change accounting for 47% of the variance in changes across domains. Change interrelations persisted at close to full strength after controlling for a comprehensive set of demographic, physical, and medical factors including educational attainment, childhood intelligence, physical function, APOE genotype, smoking status, diagnosis of hypertension, diagnosis of cardiovascular disease, and diagnosis of diabetes. Thus, the positive manifold of aging-related cognitive changes is highly robust in that it can be detected in a narrow age cohort followed over a relatively brief longitudinal period, and persists even after controlling for many potential confounders.
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影响因子：
4.1
作者：
Deary IJ;Gow AJ;Taylor MD;Corley J;Brett C;Wilson V;Campbell H;Whalley LJ;Visscher PM;Porteous DJ;Starr JM
通讯作者：
Starr JM
影响因子：
3.7
作者：
Anstey, KJ;Hofer, SM;Luszcz, MA
通讯作者：
Luszcz, MA
影响因子：
5.7
作者：
Deary, IJ;Simonotto, E;Wardlaw, JM
通讯作者：
Wardlaw, JM
影响因子：
3.7
作者：
Ferrer, E;Salthouse, TA;Schwartz, BS
通讯作者：
Schwartz, BS
影响因子：
3
作者：
Johnson, Wendy;Deary, Ian J.
通讯作者：
Deary, Ian J.