Extracellular Vesicle MicroRNA Transfer in Lung Diseases.
Extracellular Vesicle MicroRNA Transfer in Lung Diseases.
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肺部疾病中的细胞外囊泡 MicroRNA 转移
DOI：
10.3389/fphys.2017.01028
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发表时间：
2017
影响因子：
4
通讯作者：
Pan P
中科院分区：
文献类型：
--
作者：
Chen J;Hu C;Pan P
MicroRNAs （miRNAs）是单链非编码小rna，参与基因表达的转录和转录后调控。最近，mirna被证明可以通过细胞外囊泡（EVs）从宿主细胞有效地传递到靶细胞或组织。这些ev可在血液、尿液、呼出凝聚物、支气管肺泡灌洗液（BALF）和其他液体中检测到。mirna由供体细胞产生，然后包装到电动汽车中，并以完整的功能交付。它们被传递到靶细胞后，调节靶基因的翻译和靶细胞的功能。因此，EV转运的mirna已成为细胞间通讯的一种新方法。EV miRNA转移在各种肺部疾病中都有充分的证据，如慢性阻塞性肺疾病（COPD）、哮喘、肺动脉高压和急性肺损伤（ALI）。在这篇综述中，我们总结了EV miRNA转移的新发现，重点关注miR-210、miR-200、miR-17、miR-146a、miR-155和其他miRNA从原代人支气管上皮细胞（HBECs）、BALF、间充质干细胞和树突状细胞中转运的作用。
MicroRNAs (miRNAs) are single-stranded, small non-coding RNAs that ate involved in the transcriptional and post-transcriptional regulation of gene expression. Recently, miRNAs were demonstrated to be effectively delivered to a target cell or tissue from a host cell via extracellular vesicles (EVs). These EVs can be detected in blood, urine, exhaled breath condensates, bronchoalveolar lavage fluid (BALF), and other fluids. miRNAs are generated by donor cells and then packaged into EVs and delivered with intact functionality. After being delivered to the target cells, they regulate the translation of their target genes and the function of the target cells. Thus, EV transported miRNAs have become a new method for intercellular communication. EV miRNA transfer is well-documented in various pulmonary diseases, such as chronic obstructive pulmonary disease (COPD), asthma, pulmonary hypertension, and acute lung injury (ALI). In this review, we summarize the novel findings of EV miRNA transfer, focusing on the roles of miR-210, miR-200, miR-17, miR-146a, miR-155, and other miRNAs that are transported from primary human bronchial epithelial cells (HBECs), BALF, mesenchymal stem cells, and dendritic cells.
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影响因子：
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作者：
Chen J;Li C;Chen L
通讯作者：
Chen L
影响因子：
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作者：
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通讯作者：
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DOI：
10.1164/rccm.201012-2061oc
发表时间：
2011-07-15
影响因子：
24.7
作者：
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通讯作者：
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影响因子：
2.1
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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