The Role of Microvesicles Derived from Mesenchymal Stem Cells in Lung Diseases.
The Role of Microvesicles Derived from Mesenchymal Stem Cells in Lung Diseases.
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DOI：
10.1155/2015/985814
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发表时间：
2015
影响因子：
--
通讯作者：
Chen L
中科院分区：
文献类型：
--
作者：
Chen J;Li C;Chen L
微囊泡（MVs）是多种细胞释放的膜囊泡，近年来被认为是细胞间通讯的重要介质。mv作为一种载体，将蛋白质、信使RNA和microRNA （miRNA）转移到远端细胞，改变受体细胞的基因表达、增殖和分化。多项研究表明，在不同的实验模型中，间充质干细胞（MSCs）具有通过旁分泌机制逆转急性和慢性肺损伤的能力。这种旁分泌作用可能部分归因于源自间充质干细胞的MVs。msc衍生的MVs可能赋予受损细胞干细胞样表型，随后激活自我再生程序。在本文中，我们总结了msc衍生的MVs的特性和生物学活性，并描述了它们在再生医学中修复损伤组织的新治疗方法的潜力。此外，我们还概述了评估msc衍生mv在肺部疾病中的作用的研究，包括可能解释其治疗潜力的机制。最后，我们讨论了mscs衍生mv的临床应用，并提出了提高其治疗效率的几点建议。
Microvesicles (MVs) are membrane vesicles that are released by many types of cells and have recently been considered important mediators of cell-to-cell communication. MVs serve as a vehicle to transfer proteins and messenger RNA and microRNA (miRNA) to distant cells, which alters the gene expression, proliferation, and differentiation of the recipient cells. Several studies have demonstrated that mesenchymal stem cells (MSCs) have the capacity to reverse acute and chronic lung injury in different experimental models through paracrine mechanisms. This paracrine action may be partially accounted for by MVs that are derived from MSCs. MSC-derived MVs may confer a stem cell-like phenotype to injured cells with the consequent activation of self-regenerative programmers. In this review, we summarize the characteristics and biological activities of MSC-derived MVs, and we describe their potential in novel therapeutic approaches in regenerative medicine to repair damaged tissues. Additionally, we provide an overview of studies that have assessed the role of MSC-derived MVs in lung diseases, including the mechanisms that may account for their therapeutic potential. Finally, we discuss the clinical use of MSC-derived MVs with several suggestions for enhancing their therapeutic efficiency.
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影响因子：
3.7
作者：
Collino F;Deregibus MC;Bruno S;Sterpone L;Aghemo G;Viltono L;Tetta C;Camussi G
通讯作者：
Camussi G
影响因子：
3.7
作者：
Bruno S;Grange C;Collino F;Deregibus MC;Cantaluppi V;Biancone L;Tetta C;Camussi G
通讯作者：
Camussi G
影响因子：
20.3
作者：
Deregibus, Maria Chiara;Cantaluppi, Vincenzo;Camussi, Giovanni
通讯作者：
Camussi, Giovanni
影响因子：
6.1
作者：
Biancone, Luigi;Bruno, Stefania;Camussi, Giovanni
通讯作者：
Camussi, Giovanni
影响因子：
4.6
作者：
Lee JW;Gupta N;Serikov V;Matthay MA
通讯作者：
Matthay MA