Prevalence and significance of sarcopenia in multiple myeloma patients undergoing autologous hematopoietic cell transplantation.
Prevalence and significance of sarcopenia in multiple myeloma patients undergoing autologous hematopoietic cell transplantation.
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DOI：
10.1038/s41409-020-01008-9
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发表时间：
2021-01
影响因子：
4.8
通讯作者：
D'Souza A
中科院分区：
文献类型：
--
作者：
Williams A;Baruah D;Patel J;Szabo A;Chhabra S;Dhakal B;Hari P;Janz S;Stolley M;D'Souza A
肌肉减少症，定义为肌肉量的减少，可以随着年龄的增长而发生。我们进行了一项单中心回顾性分析，以评估多发性骨髓瘤（MM）肌肉质量的影响，多发性骨髓瘤是一种老年人血液肿瘤，接受了自体造血细胞移植（autoHCT）。142例符合条件的患者使用一种新的计算机断层扫描方法，通过测量L3腰肌内高密度肌肉的百分比来量化健康肌肉。在移植后的前100天评估早期移植后并发症。72例（51%）患者出现肌肉减少症，定义为高密度肌肉≤80%。肌少性肥胖，定义为肌少症和BMI30，在32例（23%）患者中发现。22例（16%）患者出现一种或多种早期并发症。心血管事件占所有并发症的36%。肌少症患者心脏并发症发生率（12.5%）高于无肌少症患者（2.9%,p=0.03）。多因素分析显示，移植时BMI升高与更差的OS相关，但与肌肉减少症无关（风险比：1.11,95%可信区间：1.02-1.22,p=0.02）。我们的分析表明，骨骼肌减少症在MM中很普遍，并且与MM移植后早期心血管并发症的增加有关。肥胖，无论是否有骨骼肌减少症，都与MM的生存率较差有关。我们的研究产生了假设生成数据，可以对考虑进行自体hct的患者进行风险分层。
Sarcopenia, defined as loss of muscle mass, can occur with aging. We conducted a single-center retrospective analysis to evaluate the impact of muscle quality in multiple myeloma (MM), a hematologic cancer of older adults, undergoing autologous hematopoietic cell transplantation (autoHCT). Healthy muscle was quantified by measuring the percent of high-density muscle within the L3 psoas muscle using a novel computed tomography method in 142 eligible patients. Early post-transplant complications were assessed in the first 100 days after transplant. Sarcopenia, defined as ≤80% high-density muscle, was found in 72 (51%) patients. Sarcopenic obesity, defined as sarcopenia and a BMI30, was found in 32 (23%) patients. One or more early complications occurred in 22 (16%) patients. Cardiovascular events accounted for 36% of all complications. Patients with sarcopenia had more cardiac complications (12.5%) than patients without (2.9%, p=0.03). Multivariate analysis revealed increased BMI at transplant, but not sarcopenia, was associated with worse OS (hazard ratio: 1.11, 95% confidence interval: 1.02–1.22, p=0.02). Our analysis suggests that sarcopenia is prevalent in MM and associated with increased early post-transplant cardiovascular complications in MM. Obesity, regardless of sarcopenia, is associated with worse survival in MM. Our study generates hypothesis-generating data to risk-stratify patients being considered for autoHCT.
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DOI：
10.1161/atvbaha.116.307156
发表时间：
2016-05-01
影响因子：
8.7
作者：
Ko, Byung-Joon;Chang, Yoosoo;Ryu, Seungho
通讯作者：
Ryu, Seungho
影响因子：
4.3
作者：
DeFilipp, Zachariah;Troschel, Fabian M.;Fintelmann, Florian J.
通讯作者：
Fintelmann, Florian J.
影响因子：
2.6
作者：
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通讯作者：
Couriel, Daniel
DOI：
10.1016/j.bbmt.2011.05.005
发表时间：
2011-12
期刊：
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
影响因子：
--
作者：
Vogl DT;Wang T;Pérez WS;Stadtmauer EA;Heitjan DF;Lazarus HM;Kyle RA;Kamble R;Weisdorf D;Roy V;Gibson J;Ballen K;Holmberg L;Bashey A;McCarthy PL;Freytes C;Maharaj D;Maiolino A;Vesole D;Hari P
通讯作者：
Hari P
影响因子：
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作者：
Zakaria HM;Elibe E;Macki M;Smith R;Boyce-Fappiano D;Lee I;Griffith B;Siddiqui F;Chang V
通讯作者：
Chang V