A novel use of 3D printing model demonstrates the effects of deteriorated trabecular bone structure on bone stiffness and strength.
A novel use of 3D printing model demonstrates the effects of deteriorated trabecular bone structure on bone stiffness and strength.
复制标题
DOI：
10.1016/j.jmbbm.2017.12.010
复制
发表时间：
2018-03
影响因子：
3.9
通讯作者：
Black MA
中科院分区：
文献类型：
--
作者：
Barak MM;Black MA
骨小梁结构对骨骼的正常力学行为至关重要。研究表明，骨质疏松症对骨小梁结构有负面影响，主要是通过降低骨体积分数（BV/TV）从而增加骨折风险。评估和量化这种结构退化影响的一个主要局限是，没有两种骨小梁结构是完全相同的。因此，当我们将一组健康骨骼与另一组经历了吸收（即BV/TV降低）的骨骼进行比较时，我们只能发现一种“平均”的力学效应。由于我们永远不会在两种状态（完整结构和退化结构）下拥有相同的样本，所以无法对每个样本的个体结构退化的力学效应进行量化。3D打印是一种有助于克服这一问题的新技术。在此我们报告一项初步研究，该研究将一个健康的3D打印骨小梁模型与模拟骨吸收后的同一模型进行比较。由于退化的结构骨模型是由健康模型衍生而来的，所以对于这种特定结构，可以直接估计（百分比形式）由于骨吸收导致的组织刚度和强度的降低。我们的结果表明，BV/TV相对较小的降低（约8%）会导致结构强度大幅降低（24%）以及结构刚度大幅降低（17%），（P<0.01）。结构强度从平均9.14±2.85兆帕降低到6.97±2.44兆帕，而结构刚度从平均282.5±63.4牛/毫米降低到233.8±51.2牛/毫米。这项研究表明，3D打印是一种新颖且有价值的工具，可用于量化结构退化对骨小梁力学性能的影响。未来，这种方法可能通过CT扫描、3D打印以及对骨吸收过度患者的个体骨骼复制品进行力学测试，帮助我们实现更好的个人骨折风险评估。
Trabecular bone structure is crucial to normal mechanical behavior of bones. Studies have shown that osteoporosis negatively affects trabecular bone structure, mainly by reducing bone volume fraction (BV/TV) and thus increasing fracture risk. One major limitation in assessing and quantifying the effect of this structural deterioration is that no two trabecular structures are identical. Thus, when we compare a group of healthy bones against a different group of bones that experienced resorption (i.e. decreased BV/TV) we only discover an “average” mechanical effect. It is impossible to quantify the mechanical effect of individual structural deterioration for each sample, simply because we never have the same sample in both states (intact and deteriorated structure). 3D printing is a new technology that can assist in overcoming this issue. Here we report a preliminary study that compares a healthy 3D printed trabecular bone model with the same model after bone resorption was simulated. Since the deteriorated structural bone model is derived from the healthy one, it is possible to directly estimate (percentage wise) the decrease of tissue stiffness and strength as a result of bone resorption for this specific structure. Our results demonstrate that a relatively small decrease in BV/TV (about 8%) leads to a dramatic decrease in structural strength (24%) and structural stiffness (17%), (P<0.01). Structural strength decreased from an average of 9.14±2.85 MPa to 6.97±2.44 MPa, while structural stiffness decreased from an average of 282.5±63.4 N/mm to 233.8±51.2 N/mm. This study demonstrates that 3D printing is a novel and valuable tool for quantifying the effect of structural deterioration on the mechanical properties of trabecular bone. In the future, this approach may help us attain better personal fracture risk assessments by CT scanning, 3D printing and mechanically testing individual bone replicas from patients suffering excessive bone resorption.
登录
查看更多内容
影响因子：
3.9
作者：
Hamed, Elham;Jasiuk, Iwona;Liszka, Tadeusz
通讯作者：
Liszka, Tadeusz
影响因子：
2.4
作者：
GOULET, RW;GOLDSTEIN, SA;FELDKAMP, LA
通讯作者：
FELDKAMP, LA
影响因子：
4.1
作者：
Homminga, J;McCreadie, BR;Huiskes, R
通讯作者：
Huiskes, R
DOI：
10.1002/jbm.b.10485
发表时间：
2003-02-15
影响因子：
3.4
作者：
Cooke, MN;Fisher, JP;Mikos, AG
通讯作者：
Mikos, AG
影响因子：
3.7
作者：
Barak, Meir M.;Lieberman, Daniel E.;Hublin, Jean-Jacques
通讯作者：
Hublin, Jean-Jacques