Menopause and Brain Health: Hormonal Changes Are Only Part of the Story.
Menopause and Brain Health: Hormonal Changes Are Only Part of the Story.
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DOI：
10.3389/fneur.2020.562275
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发表时间：
2020
影响因子：
3.4
通讯作者：
Thurston RC
中科院分区：
文献类型：
--
作者：
Maki PM;Thurston RC
大多数关于更年期和脑老化的研究都集中在性类固醇激素雌二醇的作用上，雌二醇是促进女性认知和脑老化的关键机制。新出现的文献表明，除了内源性雌二醇水平外，更年期症状，特别是血管舒缩症状（VMS）也是与绝经相关的认知和脑功能变化的关键决定因素。重要的是，这些文献显示了使用客观技术来识别VMS与记忆性能、大脑结构和大脑功能之间的关联的重要性。虽然自我报告测量是女性健康研究中重要的以患者为中心的结果，但VMS的客观测量通常与认知和大脑健康指数的关系更强。目前，断言VMS与记忆功能障碍之间的因果关系还为时过早，但初步研究结果表明，VMS患者可能在接受VMS治疗后认知能力得到改善。更一般地说，这些发现强调了调查女性认知能力下降的特定风险因素的效用。
Most studies of menopause and brain aging have focused on the role of the sex steroid hormone, estradiol, as a key mechanisms contributing to cognitive and brain aging in women. An emerging literature demonstrates that beyond endogenous estradiol levels, menopausal symptoms, particularly vasomotor symptoms (VMS), are also key determinants of menopause-related changes in cognition and brain function. Critically, that literature shows the importance of using objective techniques to identify associations of VMS with memory performance, brain structure, and brain function. While self-report measures are important patient-centered outcomes in women's health research, objective measures of VMS typically relate more strongly to indices of cognitive and brain health. Currently, it is premature to make a causal claim about VMS and memory dysfunction, but initial findings raise the possibility that women with VMS might experience an improvement in cognition with VMS treatment. More generally, these findings underscore the utility of investigating female-specific risk factors for cognitive decline.
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作者：
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