The Role of Myokines and Adipokines in Hypertension and Hypertension-related Complications.
The Role of Myokines and Adipokines in Hypertension and Hypertension-related Complications.
复制标题
肌因子和脂肪因子在高血压和高血压相关并发症中的作用。
DOI：
10.1038/s41440-019-0266-y
复制
发表时间：
2019-10
期刊：
影响因子：
--
通讯作者：
Yang D
中科院分区：
文献类型：
--
作者：
Chen K;Zhou M;Wang X;Li S;Yang D
骨骼肌和脂肪组织之间的相互作用已被确定在血压调节和高血压的发展中起关键作用。不同的脂肪因子和肌因子在高血压和高血压相关并发症中的作用尚不清楚。在本研究中，招募了98名高血压患者和24名血压正常的对照者，并对高血压相关并发症进行了额外的亚组分析。通过蛋白质液体芯片测定来测量循环骨源性因子瘦素、爱帕琳、fractalkine、脑源性神经营养因子（BDNF）、白血病抑制因子（LIF）、肌肉生长抑制素、脂肪酸结合蛋白3（FABP3）、鸢尾素、卵泡抑素相关蛋白1（FSTL 1）、制瘤素M、成纤维细胞生长因子21（FGF 21）和肌肉蛋白的水平。与对照组相比，高血压患者循环中BDNF和musclin水平降低，而leptin和irisin水平升高。Logistic回归分析显示，鸢尾素水平与收缩压呈正相关，校正后可作为高血压的独立预测因子。在非肥胖受试者中，DKK 1、BDNF和FSTL 1的浓度降低，而瘦素和鸢尾素的浓度升高。Irisin和DKK 1可能与高血压有关。其他亚组分析显示，鸢尾素与高血压相关卒中显著相关。总之，我们发现鸢尾素水平的增加与高血压和高血压相关的中风有关。这些结果表明，鸢尾素可能参与高血压的病理生理。
The cross-talk between skeletal muscle and adipose tissue has been identified to play a key role in the regulation of blood pressure and the development of hypertension. The role of different adipokines and myokines in hypertension and hypertension-related complications remains unclear. In the present study, 98 hypertensive patients and 24 normotensive controls were recruited, and additional subgroup analyses of hypertension-related complications were also performed. The levels of the circulating bone-derived factors leptin, apelin, fractalkine, brain-derived neurotrophic factor (BDNF), leukemia inhibitory factor (LIF), myostatin, fatty-acid-binding protein 3 (FABP3), irisin, follistatin-related protein 1 (FSTL1), oncostatin M, fibroblast growth factor 21 (FGF21) and musclin were measured by a protein liquid chip assay. The circulating levels of BDNF and musclin were decreased, whereas the leptin and irisin levels were increased, in hypertensive patients compared with those in the control individuals. Further logistic analysis indicated that the irisin level was positively correlated with SBP and an independent predictor for hypertension after adjustment. In nonobese subjects, the concentrations of DKK1, BDNF and FSTL1 were decreased, whereas the concentrations of leptin and irisin were increased. Irisin and DKK1 might be associated with hypertension. Additional subgroup analyses showed that irisin is significantly associated with hypertension-related stroke. In conclusion, we found that increased irisin levels are associated with hypertension and hypertension-related stroke. These findings indicate that irisin may be involved in the pathophysiology of hypertension.
登录
查看更多内容
影响因子：
5.8
作者：
Pedersen, Bente K.
通讯作者：
Pedersen, Bente K.
鸢尾素在肺缺血/再灌注损伤期间保护线粒体功能。
影响因子：
17.1
作者：
Chen K;Xu Z;Liu Y;Wang Z;Li Y;Xu X;Chen C;Xia T;Liao Q;Yao Y;Zeng C;He D;Yang Y;Tan T;Yi J;Zhou J;Zhu H;Ma J;Zeng C
通讯作者：
Zeng C
影响因子：
4.4
作者：
Asadi, Yasin;Gorjipour, Fazel;Vakili, Abedin
通讯作者：
Vakili, Abedin
DOI：
10.1016/j.jtcvs.2014.11.002
发表时间：
2015-03-01
影响因子：
6
作者：
Fihn, Stephan D.;Blankenship, James C.;Shen, Win-Kuang
通讯作者：
Shen, Win-Kuang
影响因子：
2.7
作者：
Dulian, Katarzyna;Laskowski, Radoslaw;Ziemann, Ewa
通讯作者：
Ziemann, Ewa