Presence of Fibroids on Transvaginal Ultrasonography in a Community-Based, Diverse Cohort of 996 Reproductive-Age Female Participants.
Presence of Fibroids on Transvaginal Ultrasonography in a Community-Based, Diverse Cohort of 996 Reproductive-Age Female Participants.
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DOI：
10.1001/jamanetworkopen.2023.12701
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发表时间：
2023-05-01
影响因子：
13.8
通讯作者：
Cedars, Marcelle I.
中科院分区：
文献类型：
--
作者：
Huang, David;Magaoay, Brady;Rosen, Mitchell P.;Cedars, Marcelle I.
在非临床环境中，育龄女性中患有子宫肌瘤的比例是多少？哪些种族和民族受到的影响最大？在这项对996名育龄女性参与者的横断面研究中，肌瘤的总体患病率为20%。与白色（10.7%）和西班牙裔（12.7%）参与者相比，黑人或非裔美国人（35.7%）和亚裔中国人（21.8%）参与者受到的影响不成比例。这些发现表明，医疗保健专业人员应认识到子宫肌瘤的高患病率，特别是在黑人或非洲裔美国人和亚裔中国人群体中，以促进及时诊断并减少与此病理相关的健康差异。这项横断面研究估计了美国4个最大种族和民族的女性参与者中肌瘤的患病率。肌瘤是良性子宫肿瘤，可导致显着的发病率。关于纤维瘤患病率的知识，特别是在无症状人群和亚洲和西班牙裔或拉丁裔个体中，是有限的，更好地了解受影响的群体将有助于及时诊断，并促进临床试验中的适当招募，以减少健康差异。估计子宫肌瘤在不同女性人群中的患病率。这项横断面研究包括在加州州弗朗西斯科的一个学术医疗中心前瞻性招募的未寻求生育或其他疾病治疗的女性个体。努力从美国4大种族和族裔群体（亚裔中国人、黑人或非裔美国人、西班牙裔或拉丁裔和白色人）和25 - 45岁的4个相同年龄组招募相同比例的参与者。所有参与者报告月经规律（21-35天），在入组前3个月内未使用含雌激素或孕激素的药物，并否认盆腔手术史。超声检查结果的评估是正在进行的纵向队列的一部分，初始招募时间为2006年10月至2012年9月。数据分析于2022年4月至9月进行。经阴道超声检查评估子宫肌瘤的存在和负荷。共有996名女性参与者被纳入分析，包括229名（23.0%）亚裔中国人、249名（25.0%）黑人或非裔美国人、237名（23.8%）西班牙裔或拉丁裔人和281名（28.2%）白色人。亚裔中国受试者的平均（SD）年龄为34.8（5.7）岁，黑人或非裔美国人受试者为35.4（6.1）岁，西班牙裔或拉丁裔受试者为34.8（5.3）岁，白色受试者为35.3（5.0）岁。21.8%的患者存在纤维瘤（95% CI，16.7%-27.8%）亚裔中国受试者，35.7%（95% CI，29.8%-42.0%）黑人或非裔美国人受试者，12.7%（95% CI，8.7%-17.6%），白色受试者为10.7%（95% CI，7.3%-14.9%）。黑人或非裔美国人和亚裔中国人参与者比白色参与者更有可能患子宫肌瘤（黑人或非裔美国人：调整后的比值比[OR]，4.72 [95%CI，2.72-8.18]; P < .001;亚裔中国人：调整后的OR，3.35 [95%CI，1.95-5.76]; P < .001）。在肌瘤患者中，黑人或非裔美国人参与者中多发性肌瘤的比例为48.3%，白色参与者为33.3%，西班牙裔或拉丁裔参与者为33.3%，亚裔中国参与者为26.0%（P = 0.06）。黑人或非裔美国人受试者的最大平均（SD）肌瘤直径为3.9（1.9）cm，亚裔中国受试者为3.2（1.6）cm，白色受试者为3.2（1.6）cm，西班牙裔或拉丁裔受试者为3.0（1.4）cm（P = 0.03）。在这项非临床环境中的女性参与者研究中，黑人或非洲裔美国人和亚裔中国参与者不成比例地受到子宫肌瘤的影响。西班牙裔或拉丁裔参与者与白色参与者的肌瘤负担相似。
What proportion of reproductive-age female individuals in a nonclinical setting carry uterine fibroids, and which racial and ethnic groups are most affected? In this cross-sectional study of 996 reproductive-age female participants, the overall prevalence of fibroids was 20%. Black or African American (35.7%) and Asian-Chinese (21.8%) participants were disproportionately affected compared with White (10.7%) and Hispanic (12.7%) participants. These findings suggest that health care professionals should be cognizant of the high prevalence of uterine fibroids, especially in Black or African American and Asian-Chinese groups, to facilitate timely diagnosis and reduce health disparities associated with this pathology. This cross-sectional study estimates the prevalence of fibroids in female participants from the 4 largest racial and ethnic groups in the United States. Fibroids are benign uterine tumors that can cause significant morbidity. Knowledge on fibroid prevalence, especially in the asymptomatic population and in Asian and Hispanic or Latina individuals, is limited, and a better understanding of affected groups will improve timely diagnosis and motivate appropriate recruitment in clinical trials to reduce health disparities. To estimate the prevalence of fibroids in a diverse cohort of female individuals. This cross-sectional study included female individuals not seeking treatment for fertility or other conditions who were prospectively recruited in an academic medical center in San Francisco, California. Effort was made to recruit an equal proportion of participants from 4 large racial and ethnic groups in the United States (Asian-Chinese, Black or African American, Hispanic or Latina, and White) and across 4 equal age groups between 25 and 45 years. All participants reported regular menses (21-35 days), had not used estrogen- or progestin-containing medications in the 3 months prior to enrollment, and denied history of pelvic surgery. The assessment of ultrasonography results was part of an ongoing longitudinal cohort, with initial recruitment from October 2006 to September 2012. Data analysis was performed in April to September 2022. Fibroid presence and burden as assessed by transvaginal ultrasonography. A total of 996 female participants were included in the analysis, including 229 (23.0%) Asian-Chinese, 249 (25.0%) Black or African American, 237 (23.8%) Hispanic or Latina, and 281 (28.2%) White individuals. Mean (SD) age was 34.8 (5.7) years in Asian-Chinese participants, 35.4 (6.1) years in Black or African American participants, 34.8 (5.3) years in Hispanic or Latina participants, and 35.3 (5.0) years in White participants. Fibroids were present in 21.8% (95% CI, 16.7%-27.8%) of Asian-Chinese participants, 35.7% (95% CI, 29.8%-42.0%) of Black or African American participants, 12.7% (95% CI, 8.7%-17.6%) of Hispanic or Latina participants, and 10.7% (95% CI, 7.3%-14.9%) of White participants. Black or African American and Asian-Chinese participants were more likely to have fibroids than White participants (Black or African American: adjusted odds ratio [OR], 4.72 [95% CI, 2.72-8.18]; P < .001; Asian-Chinese: adjusted OR, 3.35 [95% CI, 1.95-5.76]; P < .001). In those with fibroids, the proportion with multiple fibroids were 48.3% in Black or African American participants, 33.3% in White participants, 33.3% in Hispanic or Latina participants, and 26.0% in Asian-Chinese participants (P = .06). The largest mean (SD) fibroid diameter was 3.9 (1.9) cm in Black or African American participants, 3.2 (1.6) cm in Asian-Chinese participants, 3.2 (1.6) cm in White participants, and 3.0 (1.4) cm in Hispanic or Latina participants (P = .03). In this study of female participants in a nonclinical setting, Black or African American and Asian-Chinese participants were disproportionately affected by uterine fibroids. Hispanic or Latina participants had similar fibroid burden to White participants.
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DOI：
10.1097/gme.0b013e31825540d8
发表时间：
2012-11
期刊：
Menopause (New York, N.Y.)
影响因子：
--
作者：
Bleil ME;Adler NE;Pasch LA;Sternfeld B;Gregorich SE;Rosen MP;Cedars MI
通讯作者：
Cedars MI
DOI：
10.1038/s41370-019-0114-9
发表时间：
2020-01-01
影响因子：
4.5
作者：
Bethea, Traci N.;Wesselink, Amelia K.;Wise, Lauren A.
通讯作者：
Wise, Lauren A.
影响因子：
6.7
作者：
McQueen, Dana B.;Schufreider, Ann;Uhler, Meike L.
通讯作者：
Uhler, Meike L.
DOI：
10.1073/pnas.2208886119
发表时间：
2022-11-22
影响因子：
11.1
作者：
通讯作者：
--
DOI：
10.1186/s12940-015-0043-6
发表时间：
2015-07-15
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Branch F;Woodruff TJ;Mitro SD;Zota AR
通讯作者：
Zota AR