Inhibitory control and error monitoring by human subthalamic neurons.
Inhibitory control and error monitoring by human subthalamic neurons.
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DOI：
10.1038/tp.2014.73
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发表时间：
2014-09-09
影响因子：
6.8
通讯作者：
David O
中科院分区：
文献类型：
--
作者：
Bastin J;Polosan M;Benis D;Goetz L;Bhattacharjee M;Piallat B;Krainik A;Bougerol T;Chabardès S;David O
丘脑底核（subthalamic nucleus，简称丘脑底核）被证明与自主行动的控制有关，尤其是在涉及冲突选择或快速反应抑制的任务中。然而，在非运动功能的确切作用的cardiac仍然存在争议。首先，我们测试了功能不同的神经元群体是否支持不同的执行控制功能（如抑制控制或错误监测），即使在一个单一的subterritory的大脑皮层。我们在脑深部电刺激手术中使用微电极记录来研究重度强迫症患者执行停止信号任务时，脑皮层假定的联合边缘部分的细胞外活动。第二，手术后2-4天，使用局部场电位记录来测试的假设，即脑电振荡也可能反映执行控制信号。细胞外记录揭示了三个功能不同的神经元群体：第一个发射选择性之前和运动反应期间，第二个选择性地增加其发射率在成功的抑制控制，和最后一个发射选择性错误监测期间。此外，我们发现，在正确和不正确的行为停止过程中，β频段活动（15-35 Hz）迅速增加。两者合计，我们的研究结果提供了关键的电生理支持的假设作用的运动和认知执行控制功能的整合。
The subthalamic nucleus (STN) has been shown to be implicated in the control of voluntary action, especially during tasks involving conflicting choice alternatives or rapid response suppression. However, the precise role of the STN during nonmotor functions remains controversial. First, we tested whether functionally distinct neuronal populations support different executive control functions (such as inhibitory control or error monitoring) even within a single subterritory of the STN. We used microelectrode recordings during deep brain stimulation surgery to study extracellular activity of the putative associative-limbic part of the STN while patients with severe obsessive-compulsive disorder performed a stop-signal task. Second, 2–4 days after the surgery, local field potential recordings of STN were used to test the hypothesis that STN oscillations may also reflect executive control signals. Extracellular recordings revealed three functionally distinct neuronal populations: the first one fired selectively before and during motor responses, the second one selectively increased their firing rate during successful inhibitory control, and the last one fired selectively during error monitoring. Furthermore, we found that beta band activity (15–35 Hz) rapidly increased during correct and incorrect behavioral stopping. Taken together, our results provide critical electrophysiological support for the hypothesized role of the STN in the integration of motor and cognitive-executive control functions.
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