All the light that we can see: a new era in miniaturized microscopy.

All the light that we can see: a new era in miniaturized microscopy.
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DOI:
10.1038/s41592-018-0266-x
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发表时间:
2019-01
期刊:
影响因子:
48
通讯作者:
Golshani P
Golshani P
中科院分区:
生物学1区
文献类型:
--
作者:
Aharoni D;Khakh BS;Silva AJ;Golshani P

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神经科学的一个主要挑战是揭示大脑中已定义的神经回路是如何编码、存储、修改和检索信息的。要全面应对这一挑战,需要能够记录和操纵自然行为动物中完整神经网络活动的工具。头戴式微型显微镜正在成为应对这一挑战的关键工具。在这里,我们讨论导致神经成像工具微型化的最新工作,该领域的现状,以及开源选择的重要性和必要性。最后,我们讨论了微型显微镜的未来。
One major challenge in neuroscience is to uncover how defined neural circuits in the brain encode, store, modify, and retrieve information. Meeting this challenge comprehensively requires tools capable of recording and manipulating the activity of intact neural networks in naturally behaving animals. Head-mounted miniature microscopes are emerging as a key tool to address this challenge. Here we discuss recent work leading to the miniaturization of neural imaging tools, the current state of the art in this field, and the importance and necessity of open-source options. We finish with a discussion on what the future may hold for miniature microscopy.
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