Status Epilepticus as a Presenting Feature in Posterior Reversible Encephalopathy Syndrome: Tertiary Care Center Experience.
Status Epilepticus as a Presenting Feature in Posterior Reversible Encephalopathy Syndrome: Tertiary Care Center Experience.
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DOI：
10.5005/jp-journals-10071-24492
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发表时间：
2023-07
期刊：
影响因子：
--
通讯作者：
Prasad P
中科院分区：
文献类型：
--
作者：
Prasad P
虽然癫痫发作在可逆性后部脑病综合征（PRES）中很常见，但以癫痫持续状态（SE）为表现特征的情况却很少见。回顾性研究以SE为特征的PRES患者的临床谱和结局。根据临床表现和脑MRI检查结果诊断PRES（n = 40），随访6个月后影像学检查正常。以SE为PRES的初始表现的患者被确定。关于临床表现、病因、既往病史、治疗史、影像学检查结果、EEG和长期临床结局的基线信息。癫痫发作是31例患者（77.5%）中最常见的表现。PRES的病因为先兆子痫或子痫[n = 33（82.5%）]、高血压脑病[n = 3（7.5%）]、系统性红斑狼疮（SLE）、AIP和慢性肾衰竭（CRF），各1例患者[n = 01（2.5%）]。脑MRI显示大多数累及顶枕叶（n = 33 [82.5%]）。癫痫持续状态（全身性惊厥）是8例（20%）的表现特征。其中5例（0.5%）有慢性癫痫病史。在其余3例患者中，SLE和急性间歇性卟啉病，CRF促成SE。该研究强调了PRES的临床病因谱，并在其背景下识别SE，从而导致早期诊断和早期治疗。产前保健的作用是重要的病因的识别和治疗，血压，适当的抗癫痫药物的依从性和适当的咨询。癫痫持续状态作为可逆性后部脑病综合征的一个表现特征：三级护理中心的经验。Indian J Crit Care Med 2023;27（7）：488-492.
Though epileptic seizures are common in posterior reversible encephalopathy syndrome (PRES), status epilepticus (SE) as the presenting feature is rare. To study the clinical spectrum and outcome of patients with SE as presenting feature of PRES. This is a retrospective study. PRES was diagnosed based on the clinical features and imaging findings on brain MRI (n = 40) which became normal after 6 months follow-up imaging. Patients with SE as the initial manifestation of PRES were identified. Baseline information regarding the clinical presentation, etiology, past history of illness, treatment history, imaging findings, EEG and long-term clinical outcome. Seizure was the most common presentation seen in 31 patients (77.5%). The etiologies in PRES were preeclampsia, or eclampsia [n = 33 (82.5%)], hypertensive encephalopathy [n = 3 (7.5%)], systemic lupus erythematosus (SLE), AIP, and chronic renal failure (CRF) in one patient each [n = 01 (2.5%)]. Brain MRI showed the involvement of parieto-occipital lobes (n = 33 [82.5%]) mostly. Status epilepticus (generalized convulsive) was the presenting feature in eight cases (20%). Among them, five cases (0.5%) had a history of chronic epilepsy. In the remaining three patients, SLE and acute intermittent porphyria, CRF precipitated the SE. The study highlights the clinico-etiological spectrum of PRES and the identification of SE within its context leading to the early diagnosis and management if treated early. The role of antenatal care is important for the identification and treatment of etiologies, blood pressure, proper antiepileptic drug compliance and appropriate counseling. Prasad P. Status Epilepticus as a Presenting Feature in Posterior Reversible Encephalopathy Syndrome: Tertiary Care Center Experience. Indian J Crit Care Med 2023;27(7):488–492.
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DOI：
10.4103/ijccm.ijccm_235_17
发表时间：
2017-11
期刊：
Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
影响因子：
--
作者：
Gokhale A;Kimona A;Kantor S;Prakash S;Manhas Y
通讯作者：
Manhas Y
影响因子：
0.2
作者：
Bembalgi, Shobha;Kamate, Vishal;Shruthi, K. R.
通讯作者：
Shruthi, K. R.
影响因子：
2.8
作者：
Lindheimer, Marshall D.;Taler, Sandra J.;Cunningham, F. Gary
通讯作者：
Cunningham, F. Gary
影响因子：
2
作者：
Goyal, Gourav;Jeswani, Jitesh
通讯作者：
Jeswani, Jitesh
影响因子：
9.8
作者：
Brewer, Justin;Owens, Michelle Y.;Martin, James N., Jr.
通讯作者：
Martin, James N., Jr.