Regulation of oocyte maturation: Role of conserved ERK signaling.
Regulation of oocyte maturation: Role of conserved ERK signaling.
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DOI：
10.1002/mrd.23637
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发表时间：
2022-09
影响因子：
2.5
通讯作者：
Arur, Swathi
中科院分区：
文献类型：
--
作者：
Das, Debabrata;Arur, Swathi
在卵子发生过程中，卵母细胞在减数分裂前期I停滞，以获得恢复减数分裂、受精和早期胚胎发育的能力。在这个停滞期之后，卵母细胞恢复减数分裂以响应物种特异性激素，这一过程称为卵母细胞成熟，在排卵和受精之前。参与内分泌和自分泌/旁分泌因子和信号事件在维持前期I停滞，并恢复减数分裂是一个活跃的研究领域。在脊椎动物和无脊椎动物模式生物中的研究已经描绘了调节卵母细胞成熟的分子决定因素和信号通路。细胞周期调控因子，如细胞周期蛋白依赖性激酶（CDK 1），polo样激酶（PLK 1），Wee 1/Myt 1激酶和磷酸酶CDC 25在减数分裂恢复过程中发挥保守的作用。另一方面，细胞外信号调节激酶（ERK）在所有物种的卵母细胞成熟过程中被激活，调节物种特异性以及不同生物体之间的保守事件。本文综述了ERK信号通路在哺乳动物、非哺乳类脊椎动物和无脊椎动物（如果蝇和秀丽隐杆线虫）卵母细胞成熟过程中的一般信号机制，并重点介绍了ERK信号通路在哺乳动物、非哺乳类脊椎动物和无脊椎动物卵母细胞成熟过程中的保守和独特功能。
During oogenesis, oocytes arrest at meiotic prophase I to acquire competencies for resuming meiosis, fertilization, and early embryonic development. Following this arrested period, oocytes resume meiosis in response to species-specific hormones, a process known as oocyte maturation, that precedes ovulation and fertilization. Involvement of endocrine and autocrine/paracrine factors and signaling events during maintenance of prophase I arrest, and resumption of meiosis is an area of active research. Studies in vertebrate and invertebrate model organisms have delineated the molecular determinants and signaling pathways that regulate oocyte maturation. Cell cycle regulators, such as cyclin-dependent kinase (CDK1), polo-like kinase (PLK1), Wee1/Myt1 kinase and the phosphatase CDC25 play conserved roles during meiotic resumption. Extracellular signal-regulated kinase (ERK), on the other hand, while activated during oocyte maturation in all species, regulates both species-specific, as well as conserved events among different organisms. In this review, we synthesize the general signaling mechanisms and focus on conserved and distinct functions of ERK signaling pathway during oocyte maturation in mammals, non-mammalian vertebrates, and invertebrates such as Drosophila and Caenorhabditis elegans.
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影响因子：
--
作者：
Arur S
通讯作者：
Arur S
影响因子：
11.8
作者：
Arur, Swathi;Ohmachi, Mitsue;Berkseth, Matt;Nayak, Sudhir;Hansen, David;Zarkower, David;Schedl, Tim
通讯作者：
Schedl, Tim
DOI：
10.1073/pnas.93.14.7032
发表时间：
1996-07-09
影响因子：
11.1
作者：
Choi, TS;Fukasawa, K;VandeWoude, GF
通讯作者：
VandeWoude, GF
影响因子：
--
作者：
CHO, WK;STERN, S;BIGGERS, JD
通讯作者：
BIGGERS, JD
影响因子：
4.6
作者：
Burrows, AE;Sceurman, BK;Golden, A
通讯作者：
Golden, A