Brahma‐Related Gene 1 Inhibition Prevents Liver Fibrosis and Cholangiocarcinoma by Attenuating Progenitor Expansion

Brahma‐Related Gene 1 Inhibition Prevents Liver Fibrosis and Cholangiocarcinoma by Attenuating Progenitor Expansion
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Brahma相关基因 1 抑制通过减弱祖细胞扩增来预防肝纤维化和胆管癌

DOI:
10.1002/hep.31780
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发表时间:
2021-03
期刊:
影响因子:
13.5
通讯作者:
Hong Bu
Hong Bu
中科院分区:
医学1区
文献类型:
--
作者:
Yongjie Zhou;Yuwei Chen;Xiaoyun Zhang;Qing Xu;Zhenru Wu;Xiaoyue Cao;Mingyang Shao;Yuke Shu;Tao Lv;Changli Lu;Mingjun Xie;Tianfu Wen;Jiayin Yang;Yujun Shi;Hong Bu

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肝内胆管细胞癌(iCCA)与肝祖细胞(HPC)扩增和肝纤维化密切相关。Brahma相关基因1(Brg 1),开关/蔗糖不可发酵复合物的酶亚基,在干细胞增殖中至关重要
Intrahepatic cholangiocarcinoma (iCCA) is closely correlated with hepatic progenitor cell (HPC) expansion and liver fibrosis. Brahma‐related gene 1 (Brg1), an enzymatic subunit of the switch/sucrose nonfermentable complex that is critical in stem cell mai
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