Effects of Clozapine and other Atypical Antipsychotics on Infants Development Who Were Exposed to as Fetus: A Post-Hoc Analysis.
Effects of Clozapine and other Atypical Antipsychotics on Infants Development Who Were Exposed to as Fetus: A Post-Hoc Analysis.
复制标题
氯氮平和其他非典型抗精神病药物对胎儿时期接触的婴儿发育的影响：事后分析
DOI：
10.1371/journal.pone.0123373
复制
发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Wu R
中科院分区：
文献类型：
--
作者：
Shao P;Ou J;Peng M;Zhao J;Chen J;Wu R
目的探讨氯氮平等非典型抗精神病药物对胎儿期接触的婴儿发育的影响。方法采用Apgar评分、出生时体重、体重、身高及2、6、12月龄Bayley婴幼儿发育量表第三版（BSID-III）对33例氯氮平胎儿暴露组与30例利培酮、奥氮平、喹硫平胎儿暴露组的发育进展进行比较。比较BSID-III的认知、语言、运动、社会情绪和适应行为五个分量表得分。适当使用学生t检验和卡方分析。通过协方差分析对重复测量结果进行评价。结果63名婴儿中，58名（92.1%）完成了12个月的研究期。在2个月和6个月大时，暴露于氯氮平的婴儿BSID-III的平均适应行为评分明显低于暴露于其他非典型抗精神病药物的婴儿。更多氯氮平暴露的婴儿在2个月和6个月时的适应性行为发育迟缓（定义为亚量表得分<85）。两组婴儿在2个月、6个月和12个月时的认知、语言、运动、社交和情感方面没有差异。在2个月大时，暴露于氯氮平的婴儿（33 / 25,75.8%）比暴露于其他非典型抗精神病药物的婴儿（30 / 8,26.7%）有更多的睡眠障碍和不稳定状态（P<0.001）。结论氯氮平对2、6月龄婴儿的适应行为影响大于其他非典型抗精神病药物。临床试验注册网站NCT01479400
Objective To investigate the developmental effects of clozapine and other atypical antipsychotics on infants who were exposed to as fetus. Method The developmental progress of 33 infants who were exposed to clozapine as fetus was compared to 30 infants who were exposed to risperidone, olanzapine or quetiapine as fetus by assessing Apgar scoring, birth weight at birth, body weight, height, and the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) at months 2, 6 and 12 of age. Five subscale scores of BSID-III including cognitive, language, motor, social-emotional, and adaptive behavior were also compared. Student’s t test and Chi-square analysis were used as appropriate. Repeated measurements were evaluated by analysis of covariance. Results Of the 63 infants, 58 (92.1%) completed a 12-month study period. At the age of 2 and 6 months, mean adaptive behavior scores of BSID-III were significantly lower in clozapine-exposed infants than infants who exposed to other atypical antipsychotic at 2 and 6 months of age. More clozapine-exposed infants had delayed development (defined as the subscale score of <85) for adaptive behavior at 2 and 6 months of age. There was no difference between the two groups for cognitive, language, motor, social and emotional at 2, 6 and 12 months of age. More infants who were exposed to clozapine as fetus (25 of 33, 75.8%) had disturbed sleep and a labile state than those who were exposed to other atypical antipsychotics (8 of 30, 26.7%) during 2 months of age (P<0.001). Conclusion These results suggest that clozapine has more adaptive behavior effects on infants who were exposed to as a fetus than other atypical antipsychotics at 2 and 6 months of age. Trial Registration ClinicalTrials.gov NCT01479400
登录
查看更多内容
影响因子：
6.6
作者：
WEIDEN, PJ;OLFSON, M
通讯作者：
OLFSON, M
影响因子：
3.4
作者：
Peng, Mei;Gao, Keming;Zhao, Jingping
通讯作者：
Zhao, Jingping
影响因子：
4.5
作者：
Lin, Herng-Ching;Chen, I-Ju;Wu, Fang-Jen
通讯作者：
Wu, Fang-Jen
影响因子：
2.7
作者：
Gilad, Oded;Merlob, Paul;Klinger, Gil
通讯作者：
Klinger, Gil
影响因子：
5.3
作者：
Lindenmayer, Jean-Pierre;Liu-Seifert, Hong;Volavka, Jan
通讯作者：
Volavka, Jan