Decreased MEG beta oscillations in HIV-infected older adults during the resting state.
Decreased MEG beta oscillations in HIV-infected older adults during the resting state.
复制标题
DOI：
10.1007/s13365-013-0220-8
复制
发表时间：
2013-12
影响因子：
3.2
通讯作者：
Wilson TW
中科院分区：
文献类型：
--
作者：
Becker KM;Heinrichs-Graham E;Fox HS;Robertson KR;Sandkovsky U;O'Neill J;Swindells S;Wilson TW
抗逆转录病毒联合疗法的引入显著降低了艾滋病毒相关神经认知障碍（HAND）最严重形式的患病率。尽管有所下降，但仍有35-70%的艾滋病毒感染者继续出现轻度运动和认知障碍。尽管神经心理学研究表明，HAND影响广泛的认知功能，但由于目前没有特定的测试或生物标志物，正式的诊断仍然基于排除机会性感染和其他常见疾病。在这项研究中，我们使用脑磁图（MEG）测量了15名hiv感染的老年患者和15名人口统计学匹配的未感染对照组的静息状态下的神经活动。脑磁图是一种无创、直接的神经活动测量方法，具有良好的时空分辨率。所有脑磁图数据与结构MRI共同注册，校正头部运动，拟合区域级源模型，并进行频谱分析以量化人群水平的神经振荡活动。我们发现，与健康对照者相比，hiv感染者在双侧辅助运动区、中央旁小叶、后扣带和双侧顶叶上小叶的β振荡减少。后扣带（默认模式网络的关键组成部分）的β振荡也与患者在霍普金斯语言学习测试修订后的记忆回忆方面的得分呈正相关。这些结果表明，慢性艾滋病毒感染并不是均匀地干扰皮层功能，背内侧运动皮层和顶叶皮层的神经元群尤其受到影响。这些发现还表明静息状态MEG记录可能作为识别HAND和监测疾病进展的功能性生物标志物具有重要的前景。
The introduction of combination antiretroviral therapy significantly reduced the prevalence of the most severe form of HIV-associated neurocognitive disorders (HAND). Despite this decline, 35–70% of HIV-infected patients continue to develop mild motor and cognitive impairments. Although neuropsychological studies have shown that HAND affects a wide array of cognitive functions, a formal diagnosis is still based on the exclusion of opportunistic infections and other common ailments, as no specific tests or biomarkers are currently available. In this study, we used magnetoencephalography (MEG) to measure neural activity during the resting-state in 15 HIV-infected older patients and a demographically-matched group of 15 uninfected controls. MEG is a noninvasive and direct measure of neural activity with excellent spatiotemporal resolution. All MEG data were coregistered to structural MRI, corrected for head motion, fitted to a regional-level source model, and subjected to spectral analyses to quantify population-level neural oscillatory activity. We found that HIV-infected persons exhibited decreased beta oscillations in the supplementary motor area bilaterally, paracentral lobule, posterior cingulate, and bilateral regions of the superior parietal lobule relative to healthy controls. Beta oscillations in the posterior cingulate, a critical component of the default mode network, were also positively correlated with patient scores on the memory recall aspect of the Hopkins Verbal Learning Test-Revised. These results demonstrate that chronic HIV infection does not uniformly disturb cortical function, and that neuronal populations in dorso-medial motor and parietal cortices are especially affected. These findings also suggest that resting-state MEG recordings may hold significant promise as a functional biomarker for identifying HAND and monitoring disease progression.
登录
查看更多内容
影响因子：
11.2
作者：
Ernst, Thomas;Yakupov, Renat;Nakama, Helenna;Crocket, Grace;Cole, Michael;Watters, Michael;Ricardo-Dukelow, Mary Lynn;Chang, Linda
通讯作者：
Chang, Linda
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
3.2
作者：
Jernigan, Terry L.;Archibald, Sarah L.;Fennema-Notestine, Christine;Taylor, Michael J.;Theilmann, Rebecca J.;Julaton, Michelle D.;Notestine, Randy J.;Wolfson, Tanya;Letendre, Scott L.;Ellis, Ronald J.;Heaton, Robert K.;Gamst, Anthony C.;Franklin, Donald R., Jr.;Clifford, David B.;Collier, Ann C.;Gelman, Benjamin B.;Marra, Christina;McArthur, Justin C.;McCutchan, J. Allen;Morgello, Susan;Simpson, David M.;Grant, Igor
通讯作者：
Grant, Igor
影响因子：
3
作者：
Becker, James T.;Fabrizio, Melissa;Sudre, Gustavo;Haridis, Anna;Ambrose, Timothy;Aizenstein, Howard J.;Eddy, William;Lopez, Oscar L.;Wolk, David A.;Parkkonen, Lauri;Bagic, Anto
通讯作者：
Bagic, Anto
影响因子：
3.2
作者：
Heaton, Robert K.;Franklin, Donald R.;Ellis, Ronald J.;McCutchan, J. Allen;Letendre, Scott L.;LeBlanc, Shannon;Corkran, Stephanie H.;Duarte, Nichole A.;Clifford, David B.;Woods, Steven P.;Collier, Ann C.;Marra, Christina M.;Morgello, Susan;Mindt, Monica Rivera;Taylor, Michael J.;Marcotte, Thomas D.;Atkinson, J. Hampton;Wolfson, Tanya;Gelman, Benjamin B.;McArthur, Justin C.;Simpson, David M.;Abramson, Ian;Gamst, Anthony;Fennema-Notestine, Christine;Jernigan, Terry L.;Wong, Joseph;Grant, Igor
通讯作者：
Grant, Igor