Potential utility of resting-state magnetoencephalography as a biomarker of CNS abnormality in HIV disease.
Potential utility of resting-state magnetoencephalography as a biomarker of CNS abnormality in HIV disease.
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DOI：
10.1016/j.jneumeth.2012.02.022
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发表时间：
2012
影响因子：
3
通讯作者：
Bagic, Anto
中科院分区：
文献类型：
--
作者：
Becker, James T.;Fabrizio, Melissa;Sudre, Gustavo;Haridis, Anna;Ambrose, Timothy;Aizenstein, Howard J.;Eddy, William;Lopez, Oscar L.;Wolk, David A.;Parkkonen, Lauri;Bagic, Anto
关键词：
目前缺乏hiv相关神经认知障碍的神经成像生物标志物。我们报告了来自HIV疾病患者和风险组适当对照者的脑磁图（MEG）数据，这些数据被收集来确定静息状态下的MEG频率分布，以及24周内的稳定性。17名患者（10名HIV阳性，7名HIV阴性）完成了详细的神经行为评估和10分钟静息状态脑磁图采集，采用306通道全头部系统。24周后重复整个评估和MEG测量。计算了8个预定义传感器组在delta （0-4 Hz）、theta （4-7 Hz）、alpha （8 - 12 Hz）、beta （12-30 Hz）和low gamma （30-50 Hz）频段的相对MEG功率。在24周的随访中，闭眼时静息状态相对功率的中位稳定性为0.80，睁眼时为0.72。右侧枕部相对伽马功率(t(15) = 1.99, p < 0.06, r =−。46)和右额叶(t(15t) = 2.15, p < 0.05, r = -。48)区域与血清状态相关。年龄对δ幂的影响在血清阳性组（r2 = 0.51）大于血清阴性组（r2 = 0.11）。无论血清状态如何，高α - γ比值的个体在认知测试中的表现往往较低。24周内宽带脑磁图频率谱的稳定性支持了脑磁图作为生物标志物的实用性。MEG图谱、血清状态和认知之间的联系表明，需要进一步研究其在HAND中的潜力。
There is a lack of a neuroimaging biomarker for HIV-Associated Neurocognitive Disorder. We report magnetoencephalography (MEG) data from patients with HIV disease and risk-group appropriate controls that were collected to determine the MEG frequency profile during the resting state, and the stability of the profile over 24 weeks. 17 individuals (10 HIV+, 7 HIV−) completed detailed neurobehavioral evaluations and 10 minutes of resting-state MEG acquisition with a 306-channel whole-head system. The entire evaluation and MEG measurement were repeated 24 weeks later. Relative MEG power in the delta (0–4 Hz), theta (4–7 Hz), alpha (8–12 Hz), beta (12–30 Hz) and low gamma (30–50 Hz) bands was computed for 8 predefined sensor groups. The median stability of resting-state relative power over 24 weeks of follow-up was 0.80 with eyes closed, and 0.72 with eyes open. The relative gamma power in the right occipital (t(15) = 1.99, p < .06, r = −.46) and right frontal (t(15t) = 2.15, p < .05, r = −.48) regions was associated with serostatus. The effect of age on delta power was greater in the seropositive subjects (r2 = .51) than in the seronegative subjects (r2 = .11). Individuals with high theta-to-gamma ratios tended to have lower cognitive test performance, regardless of serostatus. The stability of the wide-band MEG frequency profiles over 24 weeks supports the utility of MEG as a biomarker. The links between the MEG profile, serostatus, and cognition suggest further research on its potential in HAND is needed.
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