Leveraging the power of ultrasound for therapeutic design and optimization.
Leveraging the power of ultrasound for therapeutic design and optimization.
复制标题
DOI：
10.1016/j.jconrel.2011.07.032
复制
发表时间：
2011-12-20
期刊：
影响因子：
--
通讯作者：
Ferrara KW
中科院分区：
文献类型：
--
作者：
Caskey CF;Hu X;Ferrara KW
造影剂增强的超声可以通过提供测量局部血流速度的技术来促进个性化的治疗策略，以选择性地成像血管内皮上的受体，并增强局部药物递送。超声造影剂是微米直径的囊泡，在血管腔室中循环，可以选择性地用超声成像。基于微泡转运的局部血流估计可以量化抗血管生成治疗引起的变化，并有助于区分血管生成机制。与靶向配体缀合的微泡附着于在疾病中上调的内皮表面受体，提供病理性脉管系统的高信噪比图像。除了成像应用之外，微泡还可用于增强局部基因和药物递送，通过改变膜和血管通透性或通过携带和局部释放货物。我们在这篇综述中的目标是提供一个概述的使用对比增强超声方法的设计和评价的治疗策略，重点是定量血流图，分子成像和增强药物输送。
Contrast agent-enhanced ultrasound can facilitate personalized therapeutic strategies by providing the technology to measure local blood flow rate, to selectively image receptors on the vascular endothelium, and to enhance localized drug delivery. Ultrasound contrast agents are micron-diameter encapsulated bubbles that circulate within the vascular compartment and can be selectively imaged with ultrasound. Microbubble transport-based estimates of local blood flow can quantify changes resulting from anti-angiogenic therapies and facilitate differentiation of angiogenic mechanisms. Microbubbles that are conjugated with targeting ligands attach to endothelial surface receptors that are upregulated in disease, providing high signal-to-noise ratio images of pathological vasculature. In addition to imaging applications, microbubbles can be used to enhance localized gene and drug delivery, either by changing membrane and vascular permeability or by carrying and locally releasing cargo. Our goal in this review is to provide an overview of the use of contrast-enhanced ultrasound methodologies in the design and evaluation of therapeutic strategies with emphases on quantitative blood flow mapping, molecular imaging, and enhanced drug delivery.
登录
查看更多内容
影响因子：
6.7
作者：
Anderson CR;Rychak JJ;Backer M;Backer J;Ley K;Klibanov AL
通讯作者：
Klibanov AL
影响因子：
2.9
作者：
Carson, Andrew R.;McTiernan, Charles F.;Lavery, Linda;Hodnick, Abigail;Grata, Michelle;Leng, Xiaoping;Wang, Jianjun;Chen, Xucai;Modzelewski, Ruth A.;Villanueva, Flordeliza S.
通讯作者：
Villanueva, Flordeliza S.
DOI：
10.1109/tbme.2009.2034533
发表时间：
2010-01
期刊：
IEEE transactions on bio-medical engineering
影响因子：
--
作者：
Choi JJ;Feshitan JA;Baseri B;Wang S;Tung YS;Borden MA;Konofagou EE
通讯作者：
Konofagou EE
影响因子：
16.1
作者：
Deelman, Leo E.;Decleves, Anne-Emilie;Rychak, Joshua J.;Sharma, Kumar
通讯作者：
Sharma, Kumar
影响因子：
37.8
作者：
Ellegala, DB;Poi, HL;Lindner, JR
通讯作者：
Lindner, JR