No increased in utero and peripartum HIV acquisition risk in HIV-exposed preterm infants.
No increased in utero and peripartum HIV acquisition risk in HIV-exposed preterm infants.
复制标题
DOI：
10.4102/sajhivmed.v24i1.1509
复制
发表时间：
2023
影响因子：
1.7
通讯作者：
Powis K
中科院分区：
文献类型：
--
作者：
Ajibola G;Mdluli C;Bennett K;Sakoi M;Batlang O;Makhema J;Lockman S;Shapiro R;Myer L;Powis K
关于感染艾滋病毒的妇女早产婴儿与足月婴儿感染艾滋病毒的风险差异的数据有限。据报道，随着妊娠WLHIV的早产增加，了解早产婴儿中艾滋病毒垂直传播的风险可以为优化诊断检测，抗逆转录病毒预防和婴儿喂养的时机提供信息。在博茨瓦纳Mpepu研究中，描述妊娠37周前出生的围产期HIV暴露婴儿与足月出生的婴儿相比，宫内与围产期HIV感染的患病率和时间，并探讨婴儿HIV感染的预测因素。利用从Mpepu研究中提取的数据，我们描述了早产儿与足月出生的婴儿获得艾滋病毒的患病率、时间和风险因素。Fisher精确检验用于检验HIV感染率和时间的差异，多变量logistic回归模型用于评估婴儿HIV感染的风险因素。2866名WLHIV婴儿被纳入该二次分析。532例（19%）早产。早产儿与足月儿（0.8% vs 0.6%，P = 0.54）、出生时（0.2% vs 0.3%，P = 1.00）或产后14 - 34天（0.6% vs 0.3%，P = 0.41）的HIV感染率无明显差异。母亲在怀孕期间未使用抗逆转录病毒药物可显著预测婴儿感染艾滋病毒，母亲在怀孕期间接受抗逆转录病毒治疗（ART）的婴儿感染艾滋病毒的风险降低了96%（校正比值比：0.003，置信区间：0.01-0.02，P < 0.001）。与足月出生的婴儿相比，胎儿暴露于艾滋病毒后早产的婴儿在子宫内和围产期获得艾滋病毒的情况没有观察到增加。
Limited data exist on the differential risk of HIV acquisition between infants born preterm versus those born at term to women living with HIV (WLHIV). With a reported increase in preterm delivery among pregnant WLHIV, understanding the risk of vertical transmission of HIV in preterm infants can inform strategies to optimise the timing of diagnostic testing, antiretroviral prophylaxis, and infant feeding. To describe the prevalence and timing of HIV acquisition, in utero versus perinatal, among infants with perinatal HIV exposure born prior to 37 weeks completed gestation age compared to those born at term in the Botswana-based Mpepu study and explore predictors of infant HIV acquisition. Using data extracted from the Mpepu study, we describe the prevalence, timing and risk factors for HIV acquisition in infants born preterm versus those born at term. Fisher exact testing was used to test for differences in prevalence and timing of HIV and a multivariable logistic regression model was used to assess risk factors for infant HIV acquisition. 2866 infants born to WLHIV were included in this secondary analysis. 532 (19%) were born preterm. There was no observed difference in the prevalence of HIV acquisition among infants born preterm versus at term overall (0.8% vs 0.6%, P = 0.54), at birth (0.2% vs 0.3%, P = 1.00) or between 14 and 34 days post-delivery (0.6% vs 0.3%, P = 0.41). The absence of maternal antiretroviral use during pregnancy significantly predicted infant HIV acquisition, with the risk of HIV acquisition reduced by 96% among infants whose mothers were taking antiretroviral treatment (ART) during pregnancy (adjusted odds ratio: 0.003, confidence interval: 0.01–0.02, P < 0.001). There was no observed increase of in utero and peripartum HIV acquisition among infants born preterm following foetal exposure to HIV compared to those born at term.
登录
查看更多内容
影响因子：
3.8
作者：
Favarato, Graziella;Townsend, Claire L.;Thorne, Claire
通讯作者：
Thorne, Claire
影响因子：
3
作者：
Short, C-E S.;Douglas, M.;Taylor, G. P.
通讯作者：
Taylor, G. P.
影响因子：
4.5
作者：
Koye DN;Zeleke BM
通讯作者：
Zeleke BM
影响因子：
1.5
作者：
Oleribe, Obinna Ositadimma;Enenche, Ede;Taylor-Robinson, Simon David
通讯作者：
Taylor-Robinson, Simon David
影响因子：
2.9
作者：
Gumbo, F. Z.;Duri, K.;Stray-Pedersen, B.
通讯作者：
Stray-Pedersen, B.