Single molecule fluorescence approaches shed light on intracellular RNAs.
Single molecule fluorescence approaches shed light on intracellular RNAs.
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DOI：
10.1021/cr400496q
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发表时间：
2014-03-26
期刊：
影响因子：
62.1
通讯作者：
Walter, Nils G.
中科院分区：
文献类型：
--
作者：
Pitchiaya, Sethuramasundaram;Heinicke, Laurie A.;Custer, Thomas C.;Walter, Nils G.
The eukaryotic cell is highly complex. Ever since Robert Hooke discovered “cells” in 1665 when training his comparably primitive microscope on a sliver of cork, scientists have aimed to identify and characterize all functional components of the cell. Around the turn of the millennium, the Human Genome Project laid open our entire cellular catalogue, but shockingly discovered that less than 21 000 protein-coding genes, just∼ 5-times the number of a bacterium such as Escherichia coli, span only∼ 1.2% of the over 3 billion base pairs of the human genome. 1− 4 This lack of proteomic inventory initially perplexed the scientific community but then spurred debates of possible underlying RNA contributions to cellular complexity. 5, 6 The Encyclopedia Of DNA Elements (ENCODE) project, an international collaborative research effort, was initiated to provide a comprehensive picture of all
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