Development of Microfabricated Magnetic Actuators for Removing Cellular Occlusion.

Development of Microfabricated Magnetic Actuators for Removing Cellular Occlusion.
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DOI:
10.1088/0960-1317/21/5/054006
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发表时间:
2011-05
期刊:
Journal of micromechanics and microengineering : structures, devices, and systems
影响因子:
--
通讯作者:
Judy JW
Judy JW
中科院分区:
其他
文献类型:
--
作者:
Lee SA;Lee H;Pinney JR;Khialeeva E;Bergsneider M;Judy JW

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Here we report on the development of torsional magnetic microactuators for displacing biological materials in implantable catheters. Static and dynamic behaviors of the devices were characterized in air and in fluid using optical experimental methods. The devices were capable of achieving large deflections (>60°) and had resonant frequencies that ranged from 70 Hz to 1.5 kHz in fluid. The effect of long-term actuation (>2.5 · 108 cycles) was quantified using resonant shift as the metric (Δf < 2%). Cell-clearing capabilities of the devices were evaluated by examining the effect of actuation on a layer of aggressively growing adherent cells. On average, actuated microdevices removed 37.4% of the adherent cell layer grown over the actuator surface. The effect of actuation time, deflection angle, and beam geometry were evaluated. The experimental results indicate that physical removal of adherent cells at the microscale is feasible using magnetic microactuation.
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