Neurotensin receptor 1 gene (NTSR1) polymorphism is associated with working memory.
Neurotensin receptor 1 gene (NTSR1) polymorphism is associated with working memory.
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DOI：
10.1371/journal.pone.0017365
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发表时间：
2011-03-04
期刊：
影响因子：
3.7
通讯作者：
Dong Q
中科院分区：
文献类型：
--
作者：
Li J;Chen C;Chen C;He Q;Li H;Li J;Moyzis RK;Xue G;Dong Q
最近的分子遗传学研究表明，多巴胺相关基因（包括多巴胺受体，转运蛋白和降解基因）和工作记忆之间存在显着关联，但对多巴胺调节基因的作用知之甚少，如与神经降压素（NT）相关的基因，在工作记忆中。最近的一项动物研究表明，NT拮抗剂管理损害工作记忆的学习任务。目前的研究调查了NT基因和人类工作记忆之间的联系。采用2-back工作记忆范式对460名健康大学生进行了测试。对NTSR 1基因的5个SNPs进行了基因分型。以每个SNP变异体为自变量，以工作记忆任务的平均准确性为因变量，进行5次ANOVA检验，以检查NTSR 1基因型是否以及如何影响工作记忆。方差分析结果显示NTSR 1基因的两个SNP（rs 4334545和rs6090453）与工作记忆显著相关。这些结果在多重比较校正后仍然有效。我们的研究结果表明，NTSR 1 SNP多态性与健康成年人工作记忆表现的差异显着相关。这一结果扩展了先前啮齿动物研究的结果，表明NT缺乏会损害工作记忆功能。未来的研究应该复制我们的发现，并扩展到其他多巴胺调节剂的检查。
Recent molecular genetics studies showed significant associations between dopamine-related genes (including genes for dopamine receptors, transporters, and degradation) and working memory, but little is known about the role of genes for dopamine modulation, such as those related to neurotensin (NT), in working memory. A recent animal study has suggested that NT antagonist administration impaired working memory in a learning task. The current study examined associations between NT genes and working memory among humans. Four hundred and sixty healthy undergraduate students were assessed with a 2-back working memory paradigm. 5 SNPs in the NTSR1 gene were genotyped. 5 ANOVA tests were conducted to examine whether and how working memory differed by NTSR1 genotype, with each SNP variant as the independent variable and the average accuracy on the working memory task as the dependent variable. ANOVA results suggested that two SNPs in the NTSR1 gene (rs4334545 and rs6090453) were significantly associated with working memory. These results survived corrections for multiple comparisons. Our results demonstrated that NTSR1 SNP polymorphisms were significantly associated with variance in working memory performance among healthy adults. This result extended previous rodent studies showing that the NT deficiency impairs the working memory function. Future research should replicate our findings and extend to an examination of other dopamine modulators.
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DOI：
10.1111/j.1749-6632.1995.tb17496.x
发表时间：
1995-01-01
期刊：
DIVERSITY OF INTERACTING RECEPTORS
影响因子：
--
作者：
LAMBERT, PD;GROSS, R;KILTS, CD
通讯作者：
KILTS, CD
影响因子：
2.5
作者：
LAURENT, P;CLERC, P;ROSTENE, W
通讯作者：
ROSTENE, W
影响因子：
2.6
作者：
Ando, J;Ono, Y;Wright, MJ
通讯作者：
Wright, MJ
影响因子：
5.3
作者：
Binder, EB;Kinkead, B;Nemeroff, CB
通讯作者：
Nemeroff, CB
影响因子：
1.6
作者：
Azmi, Norazrina;Norman, Christine;Bennett, Geoffrey W.
通讯作者：
Bennett, Geoffrey W.