Changes in the Common Carotid Artery after Radiotherapy: Wall Thickness, Calcification, and Atherosclerosis.
Changes in the Common Carotid Artery after Radiotherapy: Wall Thickness, Calcification, and Atherosclerosis.
复制标题
DOI：
10.3988/jcn.2018.14.1.35
复制
发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Kwon SU
中科院分区：
文献类型：
--
作者：
Kim BJ;Kang HG;Lee SW;Jung J;Lee MH;Kang DW;Kim JS;Kwon SU
由于接受放射治疗的喉癌患者的长期生存率有所提高，因此对放射后并发症（包括颈动脉粥样硬化）的担忧有所增加。我们跟踪了放疗后颈总动脉（CCA）的变化，并确定了潜在的危险因素。入选了1999年1月至2009年12月期间接受放射治疗并在放射治疗前后接受计算机断层扫描（CT）的喉癌患者。研究了壁厚、血管和管腔面积的变化以及钙化或动脉粥样硬化的存在。在随访CT时比较有和无动脉粥样硬化患者的人口统计学和危险因素。共入组125例患者。放疗后几个月，管壁厚度增加，管腔面积减少。这些变化与血管危险因素无关，也不是进行性的。钙化和动脉粥样硬化分别在37例（29.6%）和71例（56.8%）患者中观察到。糖尿病与钙化相关（p=0.02）。动脉粥样硬化患者的高脂血症患病率更高（28.2% vs. 11.1%，p=0.02），并且在放射后较长时间内[62.7±32.1 vs. 40.0±24.2个月（平均值±标准差），p<0.001]。动脉粥样硬化主要发生在CCA中部（n=31，24.6%），其次是胸内水平的近端CCA（n=26，20.6%）和远端CCA（n=6，4.8%）。还观察到了正性重塑，但在钙化患者中不太常见（p=0.02）。各种类型的放射后变化发生在CCA中，并且可以在放射后CT中容易地观察到。放疗后动脉粥样硬化的患病率和负担增加与基线胆固醇水平和放疗后时间密切相关。在CCA的不常见部位观察到辐射后动脉粥样硬化。
Since the long-term survival rate has improved in laryngeal cancer patients who receive radiotherapy, concerns about postradiation complications (including carotid atherosclerosis) have increased. We followed changes in the common carotid artery (CCA) after radiotherapy and identified the underlying risk factors. Consecutive patients with laryngeal cancer who underwent radiotherapy between January 1999 and December 2009 and who had received computed tomography (CT) both pre- and postradiotherapy were enrolled. Changes in the wall thickness and in the vessel and lumen areas as well as the presence of calcification or atherosclerosis were investigated. Demographics and risk factors were compared between patients with and without atherosclerosis at follow-up CT. In total, 125 patients were enrolled. The wall thickness had increased and the lumen area had decreased several months after radiotherapy. These changes were not associated with vascular risk factors and were not progressive. Calcification and atherosclerosis were observed in 37 (29.6%) and 71 (56.8%) patients, respectively. Diabetes was associated with calcification (p=0.02). The prevalence of hyperlipidemia was higher in patients with atherosclerosis (28.2% vs. 11.1%, p=0.02) and for a longer period postradiation [62.7±32.1 vs. 40.0±24.2 months (mean±SD), p<0.001]. Atherosclerosis occurred mostly in the middle portion of the CCA (n=31, 24.6%), followed by the proximal CCA at the intrathoracic level (n=26, 20.6%) and the distal CCA (n=6, 4.8%). Positive remodeling was also observed, but this was less common in patients with calcification (p=0.02). Various types of postradiation changes occur in the CCA and can be easily observed in postradiation CT. The prevalence and burden of postradiation atherosclerosis increased in a close relationship with baseline cholesterol levels and the time after radiotherapy. Postradiation atherosclerosis was observed at unusual sites of the CCA.
登录
查看更多内容
影响因子：
8.2
作者：
Kim K;Lee JH
通讯作者：
Lee JH
DOI：
10.3988/jcn.2014.10.2.140
发表时间：
2014-04
期刊：
Journal of clinical neurology (Seoul, Korea)
影响因子：
--
作者：
Moon GJ;Kim SJ;Cho YH;Ryoo S;Bang OY
通讯作者：
Bang OY
影响因子：
158.5
作者：
Forastiere, AA;Goepfert, H;Cooper, J
通讯作者：
Cooper, J
影响因子：
8.4
作者：
Dorresteijn, LDA;Kappelle, AC;Boogerd, W
通讯作者：
Boogerd, W
影响因子：
2.9
作者：
Yamagami, Hiroshi;Sakaguchi, Manabu;Kitagawa, Kazuo
通讯作者：
Kitagawa, Kazuo