The incoherent feedforward loop can provide fold-change detection in gene regulation.
The incoherent feedforward loop can provide fold-change detection in gene regulation.
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DOI：
10.1016/j.molcel.2009.11.018
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发表时间：
2009-12-11
期刊：
影响因子：
16
通讯作者：
Alon U
中科院分区：
文献类型：
--
作者：
Goentoro L;Shoval O;Kirschner MW;Alon U
许多感觉系统（例如视觉和听力）显示出与刺激相对于背景的折叠变化成正比的响应，这是与韦伯定律相关的特征。单元格：一种响应取决于输入信号中的倍数变化，而不是其绝对水平（; goentoro和kirschner，都提交；在此体积中都提出了。基因调节的机制可以提供这种折叠变化检测。激活剂调节基因的基因和反射器。i1-ffl的倍数变化检测特征适用于响应的整个形状，包括其放大器和持续时间，并且在广泛的范围内有效生化参数。
Many sensory systems, such as vision and hearing, show a response that is proportional to the fold-change in the stimulus relative to the background, a feature related to Weber’s law. Recent experiments suggest such a fold-change detection feature in signaling systems in cells: a response that depends on the fold-change in the input signal, and not on its absolute level (; Goentoro and Kirschner, submitted; both in this volume). It is therefore of interest to find molecular mechanisms of gene regulation that can provide such fold-change detection. Here we demonstrate theoretically that fold-change detection can be generated by one of the most common network motifs in transcription networks, the incoherent feedforward loop (I1-FFL), in which an activator regulates both a gene and a repressor of the gene.The fold-change detection feature of the I1-FFL applies to the entire shape of the response, including its amplitude and duration, and is valid for a wide range of biochemical parameters.
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