Diffusion MRI tractography of the developing human fetal heart.
Diffusion MRI tractography of the developing human fetal heart.
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DOI：
10.1371/journal.pone.0072795
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Sosnovik DE
中科院分区：
文献类型：
--
作者：
Mekkaoui C;Porayette P;Jackowski MP;Kostis WJ;Dai G;Sanders S;Sosnovik DE
人体心肌具有复杂的、各向异性的三维纤维结构。然而，这种各向异性模式在胎儿时期何时形成，以及人类心脏在出生时是否在结构上完全成熟，目前尚不清楚。我们的目的是在这里使用弥散张量MRI （DTI）束图来描述发育中的人类胎儿心脏纤维结构的演变。研究了妊娠10-19周的人类胎儿心脏（n = 5）。6天大的新生儿的心脏和成年人的心脏作为对照。通过计算分数各向异性指数（FA）测定心肌各向异性程度。此外，通过将心脏的主要特征向量场数值积分为相干流线来创建纤维束。在10-14周时，胎儿心脏高度各向同性，少数心束可以分离。在14-19周之间，成人心脏的各向异性开始形成。相干纤维束在19周时完全溶解。然而，19周的心肌保持弱各向异性，FA低，无明显的薄片结构。人类胎儿心脏在14-19周之前保持高度各向同性，此时心肌细胞自我排列成连贯束。这个过程滞后于心脏收缩的开始2-3个月，这可能是心肌细胞成熟和排列的先决条件。没有证据表明结缔组织支架指导这一过程可以通过DTI识别。心脏薄片结构的成熟发生在妊娠后期，并在出生后进一步发展。
Human myocardium has a complex and anisotropic 3D fiber pattern. It remains unknown, however, when in fetal life this anisotropic pattern develops and whether the human heart is structurally fully mature at birth. We aimed here to use diffusion tensor MRI (DTI) tractography to characterize the evolution of fiber architecture in the developing human fetal heart. Human fetal hearts (n = 5) between 10–19 weeks of gestation were studied. The heart from a 6-day old neonate and an adult human heart served as controls. The degree of myocardial anisotropy was measured by calculating the fractional anisotropy (FA) index. In addition, fiber tracts were created by numerically integrating the primary eigenvector field in the heart into coherent streamlines. At 10–14 weeks the fetal hearts were highly isotropic and few tracts could be resolved. Between 14–19 weeks the anisotropy seen in the adult heart began to develop. Coherent fiber tracts were well resolved by 19 weeks. The 19-week myocardium, however, remained weakly anisotropic with a low FA and no discernable sheet structure. The human fetal heart remains highly isotropic until 14–19 weeks, at which time cardiomyocytes self-align into coherent tracts. This process lags 2–3 months behind the onset of cardiac contraction, which may be a prerequisite for cardiomyocyte maturation and alignment. No evidence of a connective tissue scaffold guiding this process could be identified by DTI. Maturation of the heart’s sheet structure occurs late in gestation and evolves further after birth.
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DOI：
10.1186/1532-429x-14-70
发表时间：
2012-10-12
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Mekkaoui C;Huang S;Chen HH;Dai G;Reese TG;Kostis WJ;Thiagalingam A;Maurovich-Horvat P;Ruskin JN;Hoffmann U;Jackowski MP;Sosnovik DE
通讯作者：
Sosnovik DE
DOI：
10.1152/ajpheart.1998.275.6.h2308
发表时间：
1998-12-01
影响因子：
4.8
作者：
Scollan, DF;Holmes, A;Forder, J
通讯作者：
Forder, J
影响因子：
20.1
作者：
Phillips, Helen M.;Rhee, Hong Jun;Henderson, Deborah J.
通讯作者：
Henderson, Deborah J.
影响因子：
2.7
作者：
Hirschy, A;Schatzmann, F;Perriard, JC
通讯作者：
Perriard, JC
影响因子：
20.1
作者：
STREETER, DD;SPOTNITZ, HM;SONNENBLICK, EH
通讯作者：
SONNENBLICK, EH