Prenatal Bisphenol A Exposure is Linked to Epigenetic Changes in Glutamate Receptor Subunit Gene Grin2b in Female Rats and Humans.
Prenatal Bisphenol A Exposure is Linked to Epigenetic Changes in Glutamate Receptor Subunit Gene Grin2b in Female Rats and Humans.
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DOI：
10.1038/s41598-018-29732-9
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发表时间：
2018-07-27
影响因子：
4.6
通讯作者：
Rüegg J
中科院分区：
文献类型：
--
作者：
Alavian-Ghavanini A;Lin PI;Lind PM;Risén Rimfors S;Halin Lejonklou M;Dunder L;Tang M;Lindh C;Bornehag CG;Rüegg J
Bisphenol A (BPA) exposure has been linked to neurodevelopmental disorders and to effects on epigenetic regulation, such as DNA methylation, at genes involved in brain function. High doses of BPA have been shown to change expression and regulation of one such gene, Grin2b, in mice. Yet, if such changes occur at relevant doses in animals and humans has not been addressed. We investigated if low-dose developmental BPA exposure affects DNA methylation and expression of Grin2b in brains of adult rats. Furthermore, we assessed associations between prenatal BPA exposure and Grin2b methylation in 7-year old children. We found that Grin2b mRNA expression was increased and DNA methylation decreased in female, but not in male rats. In humans, prenatal BPA exposure was associated with increased methylation levels in girls. Additionally, low APGAR scores, a predictor for increased risk for neurodevelopmental diseases, were associated with higher Grin2b methylation levels in girls. Thus, we could link developmental BPA exposure and low APGAR scores to changes in the epigenetic regulation of Grin2b, a gene important for neuronal function, in a sexual dimorphic fashion. Discrepancies in exact locations and directions of the DNA methylation change might reflect differences between species, analysed tissues, exposure level and/or timing.
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DOI：
10.1016/j.bbrc.2003.12.065
发表时间：
2004-01-30
影响因子：
3.1
作者：
Choi, YS;Kim, S;Pak, YK
通讯作者：
Pak, YK
DOI：
10.1177/1559325815610760
发表时间：
2015-10
期刊：
Dose-response : a publication of International Hormesis Society
影响因子：
--
作者：
Gioiosa L;Palanza P;Parmigiani S;Vom Saal FS
通讯作者：
Vom Saal FS
影响因子：
2.8
作者：
Bornehag, Carl-Gustaf;Moniruzzaman, Syed;Janson, Staffan
通讯作者：
Janson, Staffan
影响因子：
2.5
作者：
Dorval, K. M.;Wigg, K. G.;Barr, C. L.
通讯作者：
Barr, C. L.
影响因子：
14.9
作者：
Karolchik D;Barber GP;Casper J;Clawson H;Cline MS;Diekhans M;Dreszer TR;Fujita PA;Guruvadoo L;Haeussler M;Harte RA;Heitner S;Hinrichs AS;Learned K;Lee BT;Li CH;Raney BJ;Rhead B;Rosenbloom KR;Sloan CA;Speir ML;Zweig AS;Haussler D;Kuhn RM;Kent WJ
通讯作者：
Kent WJ