MRI detection of brown adipose tissue with low fat content in newborns with hypothermia.
MRI detection of brown adipose tissue with low fat content in newborns with hypothermia.
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DOI：
10.1016/j.mri.2013.10.003
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发表时间：
2014-02
影响因子：
2.5
通讯作者：
Gilsanz, Vicente
中科院分区：
文献类型：
--
作者：
Hu, Houchun H.;Wu, Tai-Wei;Yin, Larry;Kim, Mimi S.;Chia, Jonathan M.;Perkins, Thomas G.;Gilsanz, Vicente
报告新生儿缺氧缺血性脑病(HIE)低温治疗后低脂肪棕色脂肪组织(BAT)的观察。当地伦理委员会批准了影像学研究。使用低翻转角（3 度）六回波质子密度加权化学位移编码水脂肪脉冲序列在 3T MRI 系统上对 10 名 HIE 新生儿（3 名男性，7 名女性，年龄范围：2-3 天）进行了研究。将锁骨上和肩胛间（颈背）BAT 和邻近皮下白色脂肪组织 (WAT) 的脂肪信号分数 (FF) 测量值与 5 名非 HIE 新生儿（其中 2 名为本研究招募的新生儿和 3 名来自先前研究的新生儿）的脂肪信号分数 (FF) 测量结果进行比较。在 HIE 新生儿中，锁骨上、肩胛间和皮下区域的 FF 范围分别为 10.3-29.9%、28.0-57.9% 和 62.6-88.0%。在非 HIE 新生儿中，该值分别为 23.7-42.2% (p=0.01)、45.4-59.5% (p=0.06) 和 67.8-86.3% (p=0.38)。从个体角度来看，锁骨上 BAT FF 始终最低，肩胛间 BAT 值较高，皮下 WAT 值最高（p<0.01）。我们推测 HIE 新生儿的低温治疗可能会促进 BAT 介导的非颤抖产热，从而导致组织细胞内脂肪储存的消耗。我们认为，与非 HIE 新生儿相比，这反映在较低的 FF 值上，特别是在锁骨上 BAT 库中。
To report the observation of brown adipose tissue (BAT) with low fat content in neonates with hypoxic-ischemic encephalopathy (HIE) after they have undergone hypothermia therapy. The local ethics committee approved the imaging study. Ten HIE neonates (3 males, 7 females, age range: 2-3 days) were studied on a 3T MRI system using a low-flip-angle (3 degrees) six-echo proton-density-weighted chemical-shift-encoded water-fat pulse sequence. Fat-signal fraction (FF) measurements of supraclavicular and interscapular (nape) BAT and adjacent subcutaneous white adipose tissues (WAT) were compared to those from five non-HIE neonates, two recruited for the present investigation and three from a previous study. In HIE neonates, the FF range for the supraclavicular, interscapular, and subcutaneous regions were 10.3-29.9%, 28.0-57.9%, and 62.6-88.0%, respectively. In non-HIE neonates, the values were 23.7-42.2% (p=0.01), 45.4-59.5% (p=0.06), and 67.8-86.3% (p=0.38), respectively. On an individual basis, supraclavicular BAT FF was consistently the lowest, interscapular BAT values were higher, and subcutaneous WAT values were the highest (p<0.01). We speculate that hypothermia therapy in HIE neonates likely promotes BAT-mediated non-shivering thermogenesis, which subsequently leads to a depletion of the tissue's intracellular fat stores. We believe this is consequently reflected in lower FF values, particularly in the supraclavicular BAT depot, in contrast to non-HIE neonates.
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影响因子：
3.3
作者：
Hernando, Diego;Liang, Zhi-Pei;Kellman, Peter
通讯作者：
Kellman, Peter
影响因子：
3.1
作者：
Garfinkle, Jarred;Sant'Anna, Guilherme Mendes;Shevell, Michael I.
通讯作者：
Shevell, Michael I.
影响因子：
3.4
作者：
LEAN, MEJ;JENNINGS, G
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JENNINGS, G
影响因子：
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通讯作者：
Reeder, Scott B.
影响因子：
5.5
作者：
DAWKINS, MJR;HULL, D
通讯作者：
HULL, D