Exercise improves cognitive responses to psychological stress through enhancement of epigenetic mechanisms and gene expression in the dentate gyrus.
Exercise improves cognitive responses to psychological stress through enhancement of epigenetic mechanisms and gene expression in the dentate gyrus.
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DOI：
10.1371/journal.pone.0004330
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发表时间：
2009
期刊：
影响因子：
3.7
通讯作者：
Reul JM
中科院分区：
文献类型：
--
作者：
Collins A;Hill LE;Chandramohan Y;Whitcomb D;Droste SK;Reul JM
我们以前已经证明，锻炼有益于抗压能力和压力应对能力。此外，我们最近报道，与基因转录有关的表观遗传变化参与了应激事件的记忆形成。鉴于增强的应对能力，在行使科目，我们调查表观遗传，基因表达和行为的变化，在4周自愿行使大鼠。当暴露在一个新的环境中时，运动组和对照组大鼠的应对方式不同。而对照组大鼠探索新的笼子为完整的30分钟期间，运动的动物只在前15分钟内这样做，之后他们回到睡眠或休息的行为。两组动物在最初的强迫游泳中表现出相似的行为反应。24 h后再次测试时，运动组大鼠表现出明显更多的不动行为和更少的挣扎和游泳。如果大鼠在新奇或初始游泳试验后2 h，即组蛋白H3磷酸乙酰化和c-Fos诱导的峰值时被杀死，则运动大鼠显示出表达组蛋白修饰和立即早期基因诱导的齿状颗粒神经元的数量显着增加。因此，无论在新笼或初始强迫游泳会话中的行为反应如何，在运动大鼠中齿状回水平的事件的影响大于对照动物。此外，鉴于我们的概念，即强迫游泳后齿状回中的神经元反应参与应激事件的记忆形成，在运动大鼠中观察到的增强的神经元反应以及在重新测试中的更高的不动性反应与报道的这些动物的认知表现改善一致。因此，在锻炼的受试者改善压力应对似乎涉及增强认知能力，可能导致不同的表观遗传机制在齿状回神经元。
We have shown previously that exercise benefits stress resistance and stress coping capabilities. Furthermore, we reported recently that epigenetic changes related to gene transcription are involved in memory formation of stressful events. In view of the enhanced coping capabilities in exercised subjects we investigated epigenetic, gene expression and behavioral changes in 4-weeks voluntarily exercised rats. Exercised and control rats coped differently when exposed to a novel environment. Whereas the control rats explored the new cage for the complete 30-min period, exercised animals only did so during the first 15 min after which they returned to sleeping or resting behavior. Both groups of animals showed similar behavioral responses in the initial forced swim session. When re-tested 24 h later however the exercised rats showed significantly more immobility behavior and less struggling and swimming. If rats were killed at 2 h after novelty or the initial swim test, i.e. at the peak of histone H3 phospho-acetylation and c-Fos induction, then the exercised rats showed a significantly higher number of dentate granule neurons expressing the histone modifications and immediate-early gene induction. Thus, irrespective of the behavioral response in the novel cage or initial forced swim session, the impact of the event at the dentate gyrus level was greater in exercised rats than in control animals. Furthermore, in view of our concept that the neuronal response in the dentate gyrus after forced swimming is involved in memory formation of the stressful event, the observations in exercised rats of enhanced neuronal responses as well as higher immobility responses in the re-test are consistent with the reportedly improved cognitive performance in these animals. Thus, improved stress coping in exercised subjects seems to involve enhanced cognitive capabilities possibly resulting from distinct epigenetic mechanisms in dentate gyrus neurons.
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影响因子：
4.7
作者：
Chandramohan, Yalini;Droste, Susanne K.;Reul, Johannes M. H. M.
通讯作者：
Reul, Johannes M. H. M.
影响因子：
5
作者：
Korte, SM;DeKloet, ER;Bohus, B
通讯作者：
Bohus, B
影响因子：
3.3
作者：
Lambert, GW;Jonsdottir, IH
通讯作者：
Jonsdottir, IH
影响因子：
3.4
作者：
Bilang-Bleuel, A;Ulbricht, S;Reul, JMHM
通讯作者：
Reul, JMHM
影响因子：
3.2
作者：
Droste, S. K.;Schweizer, M. C.;Reul, J. M. H. M.
通讯作者：
Reul, J. M. H. M.