Involvement of the thalamocortical network in TLE with and without mesiotemporal sclerosis.
Involvement of the thalamocortical network in TLE with and without mesiotemporal sclerosis.
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DOI：
10.1111/j.1528-1167.2009.02413.x
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发表时间：
2010-08
期刊：
影响因子：
5.6
通讯作者：
Weiner MW
中科院分区：
文献类型：
--
作者：
Mueller SG;Laxer KD;Barakos J;Cheong I;Finlay D;Garcia P;Cardenas-Nicolson V;Weiner MW
丘脑在颞叶癫痫（TLE）的发作传播中起着重要作用。本研究探讨了颞叶癫痫伴中颞叶硬化（TLE-MTS）和不伴海马硬化（TLE-no）的病灶、同侧丘脑和病灶外皮质结构的结构异常之间的关系。T1和高分辨率T2图像在4 T磁体上获得29名对照，15名TLE-MTS病例和14名TLE-no。丘脑体积通过将标记的图谱扭曲到每个受试者的大脑上获得。使用基于变形的形态测定法来识别丘脑体积损失的区域，并使用FreeSurfer进行皮质厚度测量。从高分辨率T2图像获得CA 1体积。在SPM 2和FreeSurfer中对基于体素和顶点的分析进行了多元回归分析和相关性分析。TLE-MTS在前丘脑有双侧体积损失，这与CA 1体积和中颞叶皮质变薄相关。TLE-no在背外侧核的体积损失不太严重，这与颞中区的变薄有关，但与颞外区变薄无关。研究结果表明，癫痫发作传播从假定的致痫灶或区域接近它到丘脑发生在TLE-MTS和TLE-no，并导致在丘脑中的局限性神经元损失。然而，癫痫蔓延到丘脑以外似乎不是颞叶癫痫广泛的颞叶外皮质异常的原因。
The thalamus plays an important role in seizure propagation in temporal lobe epilepsy (TLE). This study investigated how structural abnormalities in the focus, ipsilateral thalamus and extrafocal cortical structures relate to each other in TLE with mesiotemporal sclerosis (TLE-MTS) and without hippocampal sclerosis (TLE-no). T1 and high-resolution T2 images were acquired on a 4T magnet in 29 controls, 15 TLE-MTS cases, and 14 TLE-no. Thalamus volumes were obtained by warping a labeled atlas onto each subject’s brain. Deformation-based morphometry was used to identify regions of thalamic volume loss and FreeSurfer for cortical thickness measurements. CA1 volumes were obtained from high-resolution T2 images. Multiple regression analysis and correlation analyses for voxel- and vertex-based analyses were performed in SPM2 and FreeSurfer. TLE-MTS had bilateral volume loss in the anterior thalamus, which was correlated with CA1 volume and cortical thinning in the mesiotemporal lobe. TLE-no had less severe volume loss in the dorsal lateral nucleus, which was correlated with thinning in the mesiotemporal region but not with extratemporal thinning. The findings suggest that seizure propagation from the presumed epileptogenic focus or regions close to it into the thalamus occurs in TLE-MTS and TLE-no and results in circumscribed neuronal loss in the thalamus. However, seizure spread beyond the thalamus seems not to be responsible for the extensive extratemporal cortical abnormalities in TLE.
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影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
5.3
作者：
Bothwell, S;Meredith, GE;Farrell, M
通讯作者：
Farrell, M
影响因子：
4.1
作者：
Groenewegen, HJ;Wright, CI;Uylings, HBM
通讯作者：
Uylings, HBM
影响因子：
14.5
作者：
Guye, Maxime;Regis, Jean;Bartolomei, Fabrice
通讯作者：
Bartolomei, Fabrice
DOI：
10.1007/11566489_51
发表时间：
2005-01-01
期刊：
MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2005, PT 2
影响因子：
--
作者：
Lorenzen, P;Davis, B;Joshi, S
通讯作者：
Joshi, S