Relationships of brain white matter microstructure with clinical and MR measures in relapsing-remitting multiple sclerosis.
Relationships of brain white matter microstructure with clinical and MR measures in relapsing-remitting multiple sclerosis.
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DOI：
10.1002/jmri.22062
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发表时间：
2010-03
期刊：
影响因子：
--
通讯作者：
Fazekas F
中科院分区：
文献类型：
--
作者：
Giorgio A;Palace J;Johansen-Berg H;Smith SM;Ropele S;Fuchs S;Wallner-Blazek M;Enzinger C;Fazekas F
目的探讨多发性硬化(MS)患者脑白质(WM)弥散张量成像(DTI)微结构损伤与临床参数及磁共振成像(MRI)指标的关系。45例复发缓解(RR)MS患者，男12例，女33例，中位年龄29岁，扩展残疾状态量表(EDSS)1.5分，病程3年。创建T2病变掩膜，并使用基于区域的空间统计(TBSS)进行体素DTI分析。T2-病变体积(T2-LV)与各向异性分数(FA)显著相关(P<；0.05，校正)。结果显示，在胼胝体压部(SCC)和锥体束(PY)，EDSS评分的升高与FA的降低之间存在相关性(P=0.08)。所有FA关联都是由垂直(向主干方向)扩散系数的变化驱动的。在两年的随访中，没有发现全局和体素上的FA显著变化。在有轻微临床残疾的RR-MS患者中，与临床残疾相关的FA变化局限于特定的WM束，如SCC和PY，并由病变内垂直弥散系数的变化和NAWM的变化驱动。纵向DTI测量似乎不能描绘MS患者WM的早期病程。
To assess the relationships of microstructural damage in the cerebral white matter (WM), as measured by diffusion tensor imaging (DTI), with clinical parameters and magnetic resonance imaging (MRI) measures of focal tissue damage in patients with multiple sclerosis (MS). Forty-five relapsing-remitting (RR) MS patients (12 male, 33 female; median age = 29 years, Expanded Disability Status Scale (EDSS) = 1.5, disease duration = 3 years) were studied. T2-lesion masks were created and voxelwise DTI analyses performed with Tract-Based Spatial Statistics (TBSS). T2-lesion volume (T2-LV) was significantly (P < 0.05, corrected) correlated with fractional anisotropy (FA) in both lesions and normal-appearing WM (NAWM). Relationships (P = 0.08, corrected) between increasing EDSS score and decreasing FA were found in the splenium of the corpus callosum (sCC) and along the pyramidal tract (PY). All FA associations were driven by changes in the perpendicular (to primary tract direction) diffusivity. No significant global and voxelwise FA changes were found over a 2-year follow-up. FA changes related to clinical disability in RR-MS patients with minor clinical disability are localized to specific WM tracts such as the sCC and PY and are driven by changes in perpendicular diffusivity both within lesions and NAWM. Longitudinal DTI measurements do not seem able to chart the early disease course in the WM of MS patients.
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影响因子：
4.4
作者：
Henry, RG;Oh, JM;Pelletier, D
通讯作者：
Pelletier, D
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2.5
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Pozzilli, C
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6
作者：
Ciccarelli, O;Werring, DJ;Thompson, AJ
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5.8
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Berry, I
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作者：
Cader, S.;Johansen-Berg, H.;Matthews, P. M.
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