Nucleus of the solitary tract in the C57BL/6J mouse: Subnuclear parcellation, chorda tympani nerve projections, and brainstem connections.

Nucleus of the solitary tract in the C57BL/6J mouse: Subnuclear parcellation, chorda tympani nerve projections, and brainstem connections.
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C57BL/6J小鼠中孤立道的核:亚核拟层,鼓膜神经投影和脑干连接。

DOI:
10.1002/cne.23484
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发表时间:
2014-05-01
影响因子:
2.5
通讯作者:
Whitehead, Mark C.
Whitehead, Mark C.
中科院分区:
医学3区
文献类型:
--
作者:
Ganchrow, Donald;Ganchrow, Judith R.;Cicchini, Vanessa;Bartel, Dianna L.;Kaufman, Daniel;Girard, David;Whitehead, Mark C.

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孤束核(NST)在头端处理味觉和相关体感信息,在尾端处理一般内脏感觉信息。为了比较其与其他啮齿动物的联系,这项对 C57BL/6J 小鼠的研究提供了 NST 的亚核细胞结构分区(尼氏染色),分为吻部、中间部和尾部分裂。通过 NADPH 染色和 P2X2 免疫反应性 (IR) 进一步表征亚核。霍乱毒素 B 亚基 (CTb) 标记揭示了接受鼓索神经 (CT) 传入神经的 NST 亚核、与臂旁核 (PBN) 和网状结构 (RF) 连接的 NST 亚核以及互连 NST 亚核的亚核。 CT 终端在头端中央 (RC) 和内侧 (M) 亚核中最密集;头外侧 (RL) 亚核密度较低;腹侧 (V)、腹外侧 (VL) 和中央外侧 (CL) 亚核稀疏。 CTb注射到PBN中逆行标记上述亚核中的细胞; RC 和 M 提供最大的 PBN 投射神经元来源。桥脑传出轴突主要终止于 V 亚核和吻侧内侧 (RM) 亚核。 CTb 注射到髓质 RF 中,标记细胞和轴突末端主要位于 V 区的头端和中间 NST 水平。 NST 内的小量 CTb 注射标记了从头侧分裂到尾侧亚核的广泛投影。来自尾部分裂的投影主要互连仅限于 NST 尾部分裂的亚核;它们还与Postrema地区相连。 P2X2-IR 识别中间/尾部 NST 中央 (Ce) 亚核中可能的迷走神经末梢。 Ce 还显示出强烈的 NADPH 染色,并且不会投射到 PBN 上。 J.Comp。内罗尔。 522:1565–1596,2014 年。
The nucleus of the solitary tract (NST) processes gustatory and related somatosensory information rostrally and general viscerosensory information caudally. To compare its connections with those of other rodents, this study in the C57BL/6J mouse provides a subnuclear cytoarchitectonic parcellation (Nissl stain) of the NST into rostral, intermediate, and caudal divisions. Subnuclei are further characterized by NADPH staining and P2X2 immunoreactivity (IR). Cholera toxin subunit B (CTb) labeling revealed those NST subnuclei receiving chorda tympani nerve (CT) afferents, those connecting with the parabrachial nucleus (PBN) and reticular formation (RF), and those interconnecting NST subnuclei. CT terminals are densest in the rostral central (RC) and medial (M) subnuclei; less dense in the rostral lateral (RL) subnucleus; and sparse in the ventral (V), ventral lateral (VL), and central lateral (CL) subnuclei. CTb injection into the PBN retrogradely labels cells in the aforementioned subnuclei; RC and M providing the largest source of PBN projection neurons. Pontine efferent axons terminate mainly in V and rostral medial (RM) subnuclei. CTb injection into the medullary RF labels cells and axonal endings predominantly in V at rostral and intermediate NST levels. Small CTb injections within the NST label extensive projections from the rostral division to caudal subnuclei. Projections from the caudal division primarily interconnect subnuclei confined to the caudal division of the NST; they also connect with the area postrema. P2X2-IR identifies probable vagal nerve terminals in the central (Ce) subnucleus in the intermediate/caudal NST. Ce also shows intense NADPH staining and does not project to the PBN. J. Comp. Neurol. 522:1565–1596, 2014.
DOI: 10.1002/cne.23069
发表时间: 2012-08-15
影响因子: 2.5
作者:
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通讯作者: Bartel, Dianna L.
DOI: 10.1016/s0006-8993(98)01270-0
发表时间: 1999-03-13
期刊: BRAIN RESEARCH
影响因子: 2.9
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DOI: 10.1002/ar.1090940210
发表时间: 1946-01-01
期刊: ANATOMICAL RECORD
影响因子: --
作者:
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通讯作者: ABERCROMBIE, M
DOI: 10.1002/cne.901900211
发表时间: 1980-01-01
影响因子: 2.5
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DOI: 10.1186/1471-2202-9-96
发表时间: 2008-10-02
期刊: BMC NEUROSCIENCE
影响因子: 2.4
作者:
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