Glial responses after chorda tympani nerve injury.
Glial responses after chorda tympani nerve injury.
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DOI：
10.1002/cne.23069
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发表时间：
2012-08-15
影响因子：
2.5
通讯作者：
Bartel, Dianna L.
中科院分区：
文献类型：
--
作者：
Bartel, Dianna L.
关键词：
鼓索（CT）神经支配舌味蕾，在牙科和内耳手术期间容易受损。CT的中断导致味蕾的消失，这可能伴随着味觉障碍。由于CT通常在几周内成功再生以重新支配味蕾，因此味觉障碍的持续性可能表明中枢神经功能的改变。对其他感觉神经的外周损伤导致中枢末端的神经胶质反应，其积极地促成由神经损伤引起的异常感觉。因此，目前的研究检查了小胶质细胞和星形胶质细胞的反应，在第一个中央味觉中继-孤束核（nTS）-横断后的CT。CT的损伤导致在损伤后2-20天在形态反应性方面的显著小胶质细胞反应和小胶质细胞密度的增加。这种增加的小神经胶质细胞群体主要是由1.5-3天的小神经胶质细胞增殖引起的，这是由第2-3天之间的nTS亚部内的小神经胶质细胞迁移补充的。与其他神经损伤不同，CT损伤不会导致骨髓源性前体细胞的募集。星形胶质细胞也在nTS中反应，GFAP水平增加3天，尽管没有显示出细胞分裂的证据。GFAP水平在30天时仍然增加，此时小胶质细胞反应已经解决。这些结果表明，对CT的神经损伤导致中枢神经胶质反应，其可能参与CT损伤后的持久味觉改变。
The chorda tympani (CT) nerve innervates lingual taste buds and is susceptible to damage during dental and inner ear procedures. Interruption of the CT results in a disappearance of taste buds, which can be accompanied by taste disturbances. Because the CT usually regenerates to reinnervate taste buds successfully in a few weeks, a persistence of taste disturbances may indicate alterations in central nervous function. Peripheral injury to other sensory nerves leads to glial responses at central terminals, which actively contribute to abnormal sensations arising from nerve damage. Therefore, the current study examined microglial and astrocytic responses in the first central gustatory relay -the nucleus of the solitary tract (nTS)- after transection of the CT. Damage to the CT resulted in significant microglial responses in terms of morphological reactivity and an increased density of microglial cells from 2-20 days after injury. This increased microglial population primarily resulted from microglial proliferation from 1.5-3 days, which was supplemented by microglial migration within sub-divisions of the nTS between days 2-3. Unlike other nerve injuries, CT injury did not result in recruitment of bone marrow-derived precursors. Astrocytes also reacted in the nTS with increased levels of GFAP by 3 days, although none showed evidence of cell division. GFAP levels remained increased at 30 days by which time microglial responses had resolved. These results show that nerve damage to the CT results in central glial responses, which may participate in long lasting taste alterations following CT lesion.
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