HIV infection of non-classical cells in the brain.
HIV infection of non-classical cells in the brain.
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DOI：
10.1186/s12977-023-00616-9
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发表时间：
2023-01-13
期刊：
影响因子：
3.3
通讯作者：
中科院分区：
文献类型：
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作者：
HIV-associated neurological disorders (HAND) affect up to 50% of people living with HIV (PLWH), even in the era of combination antiretroviral therapy (cART). HIV-DNA can be detected in the cerebral spinal fluid (CSF) of approximately half of aviremic ART-suppressed PLWH and its presence is associated with poorer neurocognitive performance. HIV DNA + and HIV RNA + cells have also been observed in postmortem brain tissue of individuals with sustained cART suppression. In this review, we provide an overview of how HIV invades the brain and HIV infection of resident brain glial cells (astrocytes and microglia). We also discuss the role of resident glial cells in persistent neuroinflammation and HAND in PLWH and their potential contribution to the HIV reservoir. HIV eradication strategies that target persistently infected glia cells will likely be needed to achieve HIV cure.
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影响因子：
5.8
作者：
Chauhan A
通讯作者：
Chauhan A
影响因子：
3.3
作者：
Bergamaschi A;Pancino G
通讯作者：
Pancino G
DOI：
10.3390/v14071469
发表时间：
2022-07-02
期刊：
Viruses
影响因子：
--
作者：
通讯作者：
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影响因子：
6.4
作者：
Avalos CR;Abreu CM;Queen SE;Li M;Price S;Shirk EN;Engle EL;Forsyth E;Bullock BT;Mac Gabhann F;Wietgrefe SW;Haase AT;Zink MC;Mankowski JL;Clements JE;Gama L
通讯作者：
Gama L
影响因子：
6.2
作者：
Barat, Corinne;Proust, Alize;Tremblay, Michel J.
通讯作者：
Tremblay, Michel J.