Multisystem Inflammatory Syndrome in Neonates Born to Mothers with SARS-CoV-2 Infection (MIS-N) and in Neonates and Infants Younger Than 6 Months with Acquired COVID-19 (MIS-C): A Systematic Review.
Multisystem Inflammatory Syndrome in Neonates Born to Mothers with SARS-CoV-2 Infection (MIS-N) and in Neonates and Infants Younger Than 6 Months with Acquired COVID-19 (MIS-C): A Systematic Review.
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DOI：
10.3390/v14040750
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发表时间：
2022-04-02
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
(1)导言：有越来越多的文献描述了母亲感染SARS-CoV-2的新生儿(MIS-N)和感染SARS-CoV-2的婴儿表现为严重疾病(MIS-C)。(2)为探讨新生儿和6个月以下婴儿多系统炎症综合征的临床特点，应用系统检索的方法，检索该领域的相关文献。我们在PubMed、EMBASE和Scope中筛选了2021年10月10日之前发布的数据。(3)结果：共纳入48篇文献，其中病例报道29篇，病例系列6篇，队列研究13篇。在临床特征方面，仅有18.2%的MI-N新生儿出现发热；与以胃肠道症状为最常见表现的大龄MI-C患儿不同，我们发现，心血管功能障碍和呼吸窘迫在MI-N新生儿和新生儿/婴儿中都是常见的表现。(4)结论：我们建议所有可疑炎症性疾病的婴儿都应接受超声心动图检查，因为在新生儿和新生儿/婴儿中均可观察到心肌功能不全和冠状动脉受损。此外，我们还总结了他们是如何治疗的，并提供了一个治疗算法，以建议对这些脆弱的婴儿进行最佳处理。
(1) Introduction: There is an increasing literature describing neonates born to mothers with SARS-CoV-2 infection (MIS-N) and infants infected with SARS-CoV-2 who presented with a severe disease (MIS-C). (2) Methods: To investigate clinical features of multisystem inflammatory syndrome in neonates and infants under six months of age, we used a systematic search to retrieve all relevant publications in the field. We screened in PubMed, EMBASE and Scopus for data published until 10 October 2021. (3) Results: Forty-eight articles were considered, including 29 case reports, six case series and 13 cohort studies. Regarding clinical features, only 18.2% of MIS-N neonates presented with fever; differently from older children with MIS-C, in which gastrointestinal symptoms were the most common manifestation, we displayed that cardiovascular dysfunction and respiratory distress are the prevalent findings both in neonates with MIS-N and in neonates/infants with MIS-C. (4) Conclusions: We suggest that all infants with suspected inflammatory disease should undergo echocardiography, due to the possibility of myocardial dysfunction and damage to the coronary arteries observed both in neonates with MIS-N and in neonates/infants with MIS-C. Moreover, we also summarize how they were treated and provide a therapeutic algorithm to suggest best management of these fragile infants.
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DOI：
10.3390/pathogens10050611
发表时间：
2021-05-17
期刊：
Pathogens (Basel, Switzerland)
影响因子：
--
作者：
Auriti C;De Rose DU;Mondì V;Stolfi I;Tzialla C;On Behalf Of The Study Group Of Neonatal Infectious Diseases
通讯作者：
On Behalf Of The Study Group Of Neonatal Infectious Diseases
影响因子：
3.1
作者：
Bottari G;Damiani E;Confalone V;Scorcella C;Casarotta E;Gandolfo C;Stoppa F;Cecchetti C;Donati A
通讯作者：
Donati A
影响因子：
0.9
作者：
Agrawal G;Wazir S;Arora A;Sethi SK
通讯作者：
Sethi SK
DOI：
10.5863/1551-6776-26.7.659
发表时间：
2021-01-01
期刊：
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
影响因子：
--
作者：
Branstetter, Joshua W;Barker, Leanna;Stultz, Jeremy S
通讯作者：
Stultz, Jeremy S
影响因子：
2
作者：
Divekar, Abhay A.;Patamasucon, Pisespong;Benjamin, Joshua S.
通讯作者：
Benjamin, Joshua S.