Neurotensin is increased in serum of young children with autistic disorder.
Neurotensin is increased in serum of young children with autistic disorder.
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DOI：
10.1186/1742-2094-7-48
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发表时间：
2010-08-23
影响因子：
9.3
通讯作者：
Theoharides TC
中科院分区：
文献类型：
--
作者：
Angelidou A;Francis K;Vasiadi M;Alysandratos KD;Zhang B;Theoharides A;Lykouras L;Sideri K;Kalogeromitros D;Theoharides TC
自闭症谱系障碍（ASD）是一组在儿童早期诊断的广泛性神经发育障碍。它们与一系列“核心症状”有关，包括社交技能，语言和非语言沟通以及重复和刻板行为方面的残疾。没有明确的发病机制或诊断试验。许多患有ASD的儿童也有“过敏样”症状，但测试呈阴性，这意味着肥大细胞由非过敏性触发激活。我们通过Milliplex阵列测定了自闭症儿童（n = 19; 16名男性和3名女性;平均年龄3.0 ± 0.4岁）和健康无关对照组（n = 16; 13名男性和3名女性;平均年龄3 ± 1.2岁）中3种神经肽的血清水平，这些神经肽可以刺激肥大细胞。只有神经降压素（NT）从对照组的60.5 ± 6.0 pg/ml显著增加到自闭症障碍组的105.6 ± 12.4 pg/ml（p = 0.004）。血清β-内啡肽和P物质（SP）水平无统计学差异。NT可以刺激免疫细胞，特别是肥大细胞，和/或对脑炎症和ASD有直接作用。
Autism spectrum disorders (ASD) are a group of pervasive neurodevelopmental disorders diagnosed in early childhood. They are associated with a set of "core symptoms" that include disabilities in social interaction skills, verbal and non-verbal communication, as well as repetitive and stereotypic behaviors. There is no definite pathogenetic mechanism or diagnostic tests. Many children with ASD also have "allergic-like" symptoms, but test negative implying mast cell activation by non-allergic triggers. We measured by Milliplex arrays serum levels of 3 neuropeptides that could stimulate mast cells in children with autistic disorder (n = 19; 16 males and 3 females; mean age 3.0 ± 0.4 years) and healthy, unrelated controls (n = 16; 13 males and 3 females; mean age 3 ± 1.2 years). Only neurotensin (NT) was significantly increased from 60.5 ± 6.0 pg/ml in controls to 105.6 ± 12.4 pg/ml in autistic disorder (p = 0.004). There was no statistically significant difference in the serum levels of β-endorphin or substance P (SP). NT could stimulate immune cells, especially mast cells, and/or have direct effects on brain inflammation and ASD.
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影响因子：
3.8
作者：
Chez, Michael G.;Dowling, Tim;Kominsky, Matt
通讯作者：
Kominsky, Matt
DOI：
10.1073/pnas.93.22.12611
发表时间：
1996-10-29
影响因子：
11.1
作者：
Castagliuolo, I;Leeman, SE;Pothoulakis, C
通讯作者：
Pothoulakis, C
影响因子：
2
作者：
Liu, Jing;Zhao, Juan;Huang, Xing-Hua
通讯作者：
Huang, Xing-Hua
影响因子：
9.3
作者：
Kempuraj D;Asadi S;Zhang B;Manola A;Hogan J;Peterson E;Theoharides TC
通讯作者：
Theoharides TC
影响因子：
11.2
作者：
Nelson, KB;Grether, JK;Phillips, TM
通讯作者：
Phillips, TM