Clerodane diterpenes: sources, structures, and biological activities.
Clerodane diterpenes: sources, structures, and biological activities.
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DOI：
10.1039/c5np00137d
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发表时间：
2016-10-28
影响因子：
11.9
通讯作者：
Lee KH
中科院分区：
文献类型：
--
作者：
Li R;Morris-Natschke SL;Lee KH
氯烷二萜是一类广泛存在的次生代谢物，已在不同科的数百种植物和其他分类群的生物中发现。近年来，这些物质因其显著的生物活性，特别是对昆虫的拒食特性而引起了人们的兴趣。此外，鼠尾草中主要的活性克罗丹类物质可以作为新型的阿片受体探针，从而更深入地了解阿片受体介导的现象，并为化学研究开辟了更多的领域。这篇文章提供了从1990年到2015年发现的天然氯烷二萜的广泛报道，并跟进了1992年Merritt和Ley在同一期刊上发表的评论。综述了氯烷二萜的分布、化学分类意义、化学结构和生物活性。在有足够信息的情况下，提出了活性氯烷的构效关系（SAR）相关性和作用方式。
The clerodane diterpenoids are a widespread class of secondary metabolites and have been found in several hundreds of plant species from various families and in organisms from other taxonomic groups. These substances have attracted interest in recent years due to their notable biological activities, particularly insect antifeedant properties. In addition, the major active clerodanes of Salvia divinorum can be used as novel opioid receptor probes, allowing greater insight into opioid receptor-mediated phenomena, as well as opening additional areas for chemical investigation. This article provides extensive coverage of naturally occurring clerodane diterpenes discovered from 1990 until 2015, and follows up on the 1992 review by Merritt and Ley in this same journal. The distribution, chemotaxonomic significance, chemical structures, and biological activities of clerodane diterpenes are summarized. In the cases where sufficient information is available, structure activity relationship (SAR) correlations and mode of action of active clerodanes have been presented.
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影响因子：
1.1
作者：
Abbaszadeh, Gholamreza;Srivastava, Chitra;Walia, Suresh
通讯作者：
Walia, Suresh
影响因子：
4.6
作者：
Angel Jaime-Vasconcelos, Miguel;Antonio Frontana-Uribe, Bernardo;Cardenas, Jorge
通讯作者：
Cardenas, Jorge
影响因子：
4.7
作者：
Aviello, Gabriella;Borrelli, Francesca;Capasso, Raffaele
通讯作者：
Capasso, Raffaele
DOI：
10.1080/10575639808048869
发表时间：
1998-01-01
期刊：
NATURAL PRODUCT LETTERS
影响因子：
--
作者：
Amaral, ACF;Barnes, RA
通讯作者：
Barnes, RA
影响因子：
5.1
作者：
AVILA, D;MEDINA, JD;DEEMING, AJ
通讯作者：
DEEMING, AJ