Choroidal volume variations with age, axial length, and sex in healthy subjects: a three-dimensional analysis.
Choroidal volume variations with age, axial length, and sex in healthy subjects: a three-dimensional analysis.
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DOI：
10.1016/j.ophtha.2012.06.065
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发表时间：
2012-12
期刊：
影响因子：
13.7
通讯作者：
Freeman WR
中科院分区：
文献类型：
--
作者：
Barteselli G;Chhablani J;El-Emam S;Wang H;Chuang J;Kozak I;Cheng L;Bartsch DU;Freeman WR
使用增强深度成像 (EDI) 谱域光学相干断层扫描 (SD-OCT) 展示健康受试者的三维脉络膜体积分布，并评估其与年龄、性别和眼轴长度的关系。回顾性案例系列。来自 114 名没有视网膜或脉络膜疾病的受试者的 176 只眼睛。对在商用 SD-OCT 设备上接受 31 光栅扫描方案的健康患者进行的 EDI SD-OCT 成像研究进行了审查。脉络膜的手动分割由两名视网膜专家进行。设备内置软件自动创建黄斑脉络膜体积图和三维地形图。计算每个早期治疗糖尿病视网膜病变研究 (ETDRS) 子领域的平均脉络膜体积。回归分析用于评估黄斑脉络膜体积与年龄、性别和眼轴长度之间的相关性。脉络膜的三维地形和 ETDRS 式体积图。所有病例均获得了脉络膜的三维地形图和体积图。中心环的平均脉络膜体积为 0.228 ± 0.077 mm3，总 ETDRS 网格的平均脉络膜体积为 7.374 ± 2.181 mm3。鼻象限显示脉络膜体积最低，上象限最高。颞侧和下象限没有显示出不同的脉络膜体积值。所有 EDTRS 环中的脉络膜体积与调整年龄后的眼轴长度显着相关（P<0.0001），与调整眼轴长度后的年龄显着相关（P<0.0001），与调整眼轴长度后的性别显着相关（P<0.05）。脉络膜体积每十年减少 0.54 mm3 (7.32%)，眼轴长度每增加 0.56 mm3 (7.59%)。男性的脉络膜体积比女性大 7.37%。 EDI SD-OCT 是一种非侵入性且耐受性良好的手术，具有出色的可视化脉络膜三维地形并使用手动分割测量后极脉络膜体积的出色能力。年龄和眼轴长度与脉络膜体积呈负相关，很可能导致老年和高度近视患者视网膜代谢支持的变化。在解释脉络膜 EDI SD-OCT 扫描时应考虑性别差异。
To demonstrate the three-dimensional choroidal volume distribution in healthy subjects using enhanced depth imaging (EDI) spectral-domain optical coherence tomography (SD-OCT) and to evaluate its association with age, sex, and axial length. Retrospective case series. One hundred and seventy six eyes from 114 subjects with no retinal or choroidal disease. EDI SD-OCT imaging studies for healthy patients who had undergone a 31-raster scanning protocol on a commercial SD-OCT device were reviewed. Manual segmentation of the choroid was performed by two retinal specialists. Macular choroidal volume map and three-dimensional topography were automatically created by the built-in software of the device. Mean choroidal volume was calculated for each Early Treatment Diabetic Retinopathy Study (ETDRS) subfield. Regression analyses were used to evaluate the correlation between macular choroidal volume and age, sex, and axial length. Three-dimensional topography and ETDRS-style volume map of the choroid. Three-dimensional topography of the choroid and volume map was obtained in all cases. The mean choroidal volume was 0.228 ± 0.077 mm3 for the center ring and 7.374 ± 2.181 mm3 for the total ETDRS grid. The nasal quadrant showed the lowest choroidal volume, and the superior quadrant the highest. The temporal and inferior quadrants did not show different choroidal volume values. Choroidal volume in all the EDTRS rings was significantly correlated with axial length after adjustment for age (P<0.0001), with age after adjustment for axial length (P<0.0001) and with sex after adjustment for axial length (P<0.05). Choroidal volume decreases by 0.54 mm3 (7.32%) for every decade and by 0.56 mm3 (7.59%) for every mm of axial length. Males have a 7.37% greater choroidal volume compared to that of females. EDI SD-OCT is non-invasive and well-tolerated procedure with an excellent ability to visualize three-dimensional topography of the choroid and to measure choroidal volume at the posterior pole using manual segmentation. Age and axial length are inversely correlated with choroidal volume, most likely leading to changes in retinal metabolic support in old and high myopic patients. Sexual differences should be considered when interpreting an EDI SD-OCT scan of the choroid.
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影响因子：
4.4
作者：
Ikuno, Yasushi;Kawaguchi, Kana;Yasuno, Yoshiaki
通讯作者：
Yasuno, Yoshiaki
影响因子：
4.4
作者：
Esmaeelpour, Marieh;Povazay, Boris;Drexler, Wolfgang
通讯作者：
Drexler, Wolfgang
DOI：
10.1097/iae.0b013e3181be0a83
发表时间：
2009-11-01
影响因子：
3.3
作者：
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通讯作者：
Spaide, Richard F.
影响因子：
3.7
作者：
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通讯作者：
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影响因子：
3.4
作者：
Fitzgerald, MEC;Wildsoet, CF;Reiner, A
通讯作者：
Reiner, A