Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake.
Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake.
复制标题
DOI：
10.1038/nn.3510
复制
发表时间：
2013-10
影响因子：
25
通讯作者：
Hjelmeland, Anita B.
中科院分区：
文献类型：
--
作者：
Flavahan, William A.;Wu, Qiulian;Hitomi, Masahiro;Rahim, Nasiha;Kim, Youngmi;Sloan, Andrew E.;Weil, Robert J.;Nakano, Ichiro;Sarkaria, Jann N.;Stringer, Brett W.;Day, Bryan W.;Li, Meizhang;Lathia, Justin D.;Rich, Jeremy N.;Hjelmeland, Anita B.
像所有癌症一样，脑肿瘤需要持续的能量来源和分子资源来产生新的细胞。在正常大脑中，葡萄糖是一种必需的神经燃料，但血脑屏障限制了其输送。我们现在报道，营养限制有助于肿瘤的进展，通过富集脑肿瘤起始细胞（BTIC），由于优先BTIC生存和适应非BTIC通过收购BTIC功能。BTIC通过选择高亲和力神经元葡萄糖转运蛋白3型（Glut 3，SLC 2A 3）来竞争葡萄糖摄取。BTIC优先表达Glut 3，靶向Glut 3抑制BTIC生长和致瘤潜力。Glut 3，而不是Glut 1，与脑肿瘤和其他癌症的生存率低相关;因此，TIC可以以高亲和力提取营养物质。由于代谢改变代表了癌症的标志，代谢重编程可能会指示肿瘤的层次结构，并预示着预后不良。
Like all cancers, brain tumors require a continuous source of energy and molecular resources for new cell production. In normal brain, glucose is an essential neuronal fuel, but the blood-brain barrier limits its delivery. We now report that nutrient restriction contributes to tumor progression by enriching for brain tumor initiating cells (BTICs) due to preferential BTIC survival and adaptation of non-BTICs through acquisition of BTIC features. BTICs outcompete for glucose uptake by co-opting the high affinity neuronal glucose transporter, type 3 (Glut3, SLC2A3). BTICs preferentially express Glut3 and targeting Glut3 inhibits BTIC growth and tumorigenic potential. Glut3, but not Glut1, correlates with poor survival in brain tumors and other cancers; thus, TICs may extract nutrients with high affinity. As altered metabolism represents a cancer hallmark, metabolic reprogramming may instruct the tumor hierarchy and portend poor prognosis.
登录
查看更多内容
影响因子：
5.2
作者：
Madhavan, Subha;Zenklusen, Jean-Claude;Kotliarov, Yuri;Sahni, Himanso;Fine, Howard A.;Buetow, Kenneth
通讯作者：
Buetow, Kenneth
DOI：
10.4161/cc.8.20.9701
发表时间：
2009-10-15
期刊：
Cell cycle (Georgetown, Tex.)
影响因子：
--
作者：
Heddleston JM;Li Z;McLendon RE;Hjelmeland AB;Rich JN
通讯作者：
Rich JN
影响因子：
64.8
作者：
Lu, Chao;Ward, Patrick S.;Kapoor, Gurpreet S.;Rohle, Dan;Turcan, Sevin;Abdel-Wahab, Omar;Edwards, Christopher R.;Khanin, Raya;Figueroa, Maria E.;Melnick, Ari;Wellen, Kathryn E.;O'Rourke, Donald M.;Berger, Shelley L.;Chan, Timothy A.;Levine, Ross L.;Mellinghoff, Ingo K.;Thompson, Craig B.
通讯作者：
Thompson, Craig B.
影响因子：
1.5
作者：
Chung, JK;Lee, YJ;Lee, MC
通讯作者：
Lee, MC
影响因子：
4.2
作者：
Charnley, N.;Airley, R.;Price, P.
通讯作者：
Price, P.