Serum metabolites as potential biomarkers for diagnosis of knee osteoarthritis.
Serum metabolites as potential biomarkers for diagnosis of knee osteoarthritis.
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DOI：
10.1155/2015/684794
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Zhang Q;Li H;Zhang Z;Yang F;Chen J
膝关节骨关节炎（OA）是一种高度流行的慢性退行性关节疾病，主要影响老年人群。本研究的目的是研究血清特征代谢物作为早期诊断膝关节OA的潜在生物标志物。采用超高效液相色谱-质谱联用技术分析了40例膝关节OA患者和20例健康对照（HC）的总体血清代谢谱。OA特异性代谢谱的建立，可以清楚地区分与HC的OA患者。与HC相比，OA患者中参与氨基酸、嘌呤、能量、糖酵解、脂肪酸和脂质代谢的14种代谢物发生显著改变。这些代谢产物可能用作诊断膝关节OA的生物标志物。
Knee osteoarthritis (OA) is a highly prevalent chronic degenerative joint disease that mainly affects the elderly population. The aim of this study was to investigate serum signature metabolites as potential biomarkers for early diagnosis of knee OA. Global serum metabolic profiles of 40 patients with knee OA and 20 healthy controls (HC) were analyzed by ultra-performance liquid chromatography coupled to mass spectrometry. An OA-specific metabolic profile was established that can clearly discriminate patients with OA from HCs. Fourteen metabolites that are involved in the metabolism of amino acids, purine, energy, glycolysis, fatty acids, and lipids were significantly altered in patients with OA compared to HCs. These metabolites could be potentially used as biomarkers for the diagnosis of knee OA.
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影响因子：
4.9
作者：
Madsen RK;Lundstedt T;Gabrielsson J;Sennbro CJ;Alenius GM;Moritz T;Rantapää-Dahlqvist S;Trygg J
通讯作者：
Trygg J
影响因子：
6.2
作者：
Gjesdal, Clara Gram;Vollset, Stein Emil;Tell, Grethe S.
通讯作者：
Tell, Grethe S.
影响因子：
3.3
作者：
Park, Su-Jung;Kim, Ki-Jo;Cho, Chul-Soo
通讯作者：
Cho, Chul-Soo
影响因子：
4
作者：
DIXON, JS;SITTON, NG;BIRD, HA
通讯作者：
BIRD, HA
影响因子：
4.1
作者：
Medina, S.;Dominguez-Perles, R.;Gil-Izquierdo, A.
通讯作者：
Gil-Izquierdo, A.