The impact of environmental metals in young urbanites' brains.
The impact of environmental metals in young urbanites' brains.
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DOI：
10.1016/j.etp.2012.02.006
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发表时间：
2013-07
期刊：
影响因子：
--
通讯作者：
Guilarte TR
中科院分区：
文献类型：
--
作者：
Calderón-Garcidueñas L;Serrano-Sierra A;Torres-Jardón R;Zhu H;Yuan Y;Smith D;Delgado-Chávez R;Cross JV;Medina-Cortina H;Kavanaugh M;Guilarte TR
暴露于空气污染与墨西哥城儿童和年轻人的认知和嗅觉障碍、氧化应激、神经炎症和神经退化有关，包括额叶过度磷酸化的tau和弥漫性淀粉样斑块。墨西哥城居民长期暴露在超过年度标准(15μ克/立方米)的细颗粒物(PM2.5)浓度(含有毒燃烧和工业金属)以及受污染的水和土壤中。在这里，我们试图解决两个空气污染目标：12名对照的额叶和嗅球对47名墨西哥城儿童和年轻人的大脑区域特定影响以及关键的神经炎症和DNA修复反应，这些儿童和年轻人的平均年龄为33.06±4.8岁。目标组织的电感耦合等离子体质谱(金属分析)和实时聚合酶链式反应(检测COX2、IL1DNA和β修复基因)。墨西哥城居民与PM相关的金属浓度较高：锰(p=0.003)、镍和铬(p=0.02)，以及额叶COX2mRNA(p=0.008)和IL1β(p=0.0002)和COX2(p=0.005)嗅球，表明神经炎症。额叶金属与嗅球DNA修复基因以及额叶和海马炎性基因相关。暴露者额叶锰、钴、硒随年龄增长而增加。综上所述，这些发现表明，PM-金属神经毒性会导致城市年轻人的大脑损伤，嗅球是空气污染的目标，并参与神经炎症反应，而且由于墨西哥城城区金属浓度差异很大，居住地点必须与中枢神经系统有害影响的风险相结合，特别是在儿童中。
Air pollution exposures are linked to cognitive and olfaction deficits, oxidative stress, neuroinflammation and neurodegeneration including frontal hyperphosphorilated tau and diffuse amyloid plaques in Mexico City children and young adults. Mexico City residents are chronically exposed to fine particulate matter (PM2.5) concentrations (containing toxic combustion and industrial metals) above the annual standard (15 μg/m3) and to contaminated water and soil. Here, we sought to address the brain-region-specific effects of metals and key neuroinflammatory and DNA repair responses in two air pollution targets: frontal lobe and olfactory bulb from 12 controls v 47 Mexico City children and young adults average age 33.06 ± 4.8 SE years. Inductively coupled plasma mass spectrometry (metal analysis) and real time PCR (for COX2, IL1β and DNA repair genes) in target tissues. Mexico City residents had higher concentrations of metals associated with PM: manganese (p=0.003), nickel and chromium (p=0.02) along with higher frontal COX2 mRNA (p=0.008) and IL1β (p=0.0002) and COX2 (p=0.005) olfactory bulb indicating neuroinflammation. Frontal metals correlated with olfactory bulb DNA repair genes and with frontal and hippocampal inflammatory genes. Frontal manganese, cobalt and selenium increased with age in exposed subjects. Together, these findings suggest PM-metal neurotoxicity causes brain damage in young urbanites, the olfactory bulb is a target of air pollution and participates in the neuroinflammatory response and since metal concentrations vary significantly in Mexico City urban sub-areas, place of residency has to be integrated with the risk for CNS detrimental effects particularly in children.
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影响因子：
2.5
作者：
Calderon-Garciduenas, Lilian;Engle, Randall;D'Angiulli, Amedeo
通讯作者：
D'Angiulli, Amedeo
影响因子：
3.8
作者：
Calderón-Garcidueñas, L;Mora-Tiscareño, A;Devlin, B
通讯作者：
Devlin, B
DOI：
10.1016/1055-8330(95)90023-3
发表时间：
1995-09-01
期刊：
NEURODEGENERATION
影响因子：
--
作者：
ALI, SF;DUHART, HM;SLIKKER, W
通讯作者：
SLIKKER, W
影响因子：
15.9
作者：
Block, Michelle L.;Calderon-Garciduenas, Lilian
通讯作者：
Calderon-Garciduenas, Lilian
影响因子：
2.1
作者：
Calderon-Garciduenas, L.;Villarreal-Calderon, R.;Reed, W.
通讯作者：
Reed, W.