Depth sensitivity and image reconstruction analysis of dense imaging arrays for mapping brain function with diffuse optical tomography.
Depth sensitivity and image reconstruction analysis of dense imaging arrays for mapping brain function with diffuse optical tomography.
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DOI：
10.1364/ao.48.00d137
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发表时间：
2009-04-01
期刊：
影响因子：
1.9
通讯作者：
Culver JP
中科院分区：
文献类型：
--
作者：
Dehghani H;White BR;Zeff BW;Tizzard A;Culver JP
由于头部的大尺寸和几何形状以及区分不同深度处的信号的期望，用于人类神经成像的漫射光学断层扫描（DOT）仪器的开发具有挑战性。解决这个问题的一种方法是使用密集的成像阵列，该阵列包含在不同的源-探测器距离处的测量。我们以前开发了一个高密度DOT系统，能够获得视网膜定位测量与功能磁共振成像和正电子发射断层扫描。高密度DOT神经成像的进一步扩展需要对测量和成像灵敏度进行全面研究，其中包括头部的复杂几何形状，包括头部曲率和分层组织结构。我们目前的数值模拟使用的成人头部的有限元模型来研究作为成像阵列和数据采样策略的函数的测量信号的灵敏度。具体来说，我们量化的成像灵敏度在大脑内（包括深度超过表层皮层脑回）作为增加的最大源检测器分离的数据中包括的功能。通过使用深度相关的灵敏度分析，表明对于矩形网格[具有1.3 cm的第一最近邻（NN）间距]，第二NN测量足以记录沿大脑皮层脑回表面的吸收变化（脑组织深度<5 mm）。使用第四和第五NN测量将允许向下成像到皮质沟（脑组织深度> 15 mm）。
The development of diffuse optical tomography (DOT) instrumentation for neuroimaging of humans is challenging due to the large size and the geometry of the head and the desire to distinguish signals at different depths. One approach to this problem is to use dense imaging arrays that incorporate measurements at different source–detector distances. We previously developed a high-density DOT system that is able to obtain retinotopic measurements in agreement with functional magnetic resonance imaging and positron emission tomography. Further extension of high-density DOT neuroimaging necessitates a thorough study of the measurement and imaging sensitivity that incorporates the complex geometry of the head—including the head curvature and layered tissue structure. We present numerical simulations using a finite element model of the adult head to study the sensitivity of the measured signal as a function of the imaging array and data sampling strategy. Specifically, we quantify the imaging sensitivity available within the brain (including depths beyond superficial cortical gyri) as a function of increasing the maximum source–detector separation included in the data. Through the use of depth related sensitivity analysis, it is shown that for a rectangular grid [with 1.3 cm first nearest neighbor (NN) spacing], second NN measurements are sufficient to record absorption changes along the surface of the brain’s cortical gyri (brain tissue depth <5 mm). The use of fourth and fifth NN measurements would permit imaging down into the cortical sulci (brain tissue depth >15 mm).
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影响因子：
--
作者：
Dehghani, Hamid;Eames, Matthew E.;Yalavarthy, Phaneendra K.;Davis, Scott C.;Srinivasan, Subhadra;Carpenter, Colin M.;Pogue, Brian W.;Paulsen, Keith D.
通讯作者：
Paulsen, Keith D.
影响因子：
1.9
作者：
Custo, Anna;Wells, William M., III;Boas, David A.
通讯作者：
Boas, David A.
影响因子：
2.5
作者：
Fuchino, Yutaka;Nagao, Masahiro;Yoro, Takeshi
通讯作者：
Yoro, Takeshi
DOI：
10.1364/josaa.18.000940
发表时间：
2001-04-01
影响因子：
1.9
作者：
Ripoll, J;Nieto-Vesperinas, M;Arridge, SR
通讯作者：
Arridge, SR
影响因子：
2.8
作者：
Srinivasan, S;Pogue, BW;Paulsen, KD
通讯作者：
Paulsen, KD