Near infrared optical tomography using NIRFAST: Algorithm for numerical model and image reconstruction.
Near infrared optical tomography using NIRFAST: Algorithm for numerical model and image reconstruction.
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DOI：
10.1002/cnm.1162
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发表时间：
2008-08-15
影响因子：
--
通讯作者：
Paulsen, Keith D.
中科院分区：
文献类型：
--
作者：
Dehghani, Hamid;Eames, Matthew E.;Yalavarthy, Phaneendra K.;Davis, Scott C.;Srinivasan, Subhadra;Carpenter, Colin M.;Pogue, Brian W.;Paulsen, Keith D.
关键词：
漫射光学断层扫描，也被称为近红外断层扫描，一直在研究中，用于组织的非侵入性功能成像，特别是用于乳腺癌或其他软组织病变的检测和表征。为了从临床数据中获得准确的建模和图像重建，已经进行了大量的工作。NIRFAST是一个建模和图像重建包，它能够从测量数据进行单波长和多波长光学或功能成像。本文介绍了建模技术和图像重建算法背后的理论，并给出了2D和3D示例来演示其功能。结果表明，三维建模可以结合多个波长的测量数据来重建组织内的发色团浓度。此外，可以恢复散射光谱，这是由组织中存在的主要的mie型散射引起的。总体而言，本文在NIRFAST软件包的背景下，对漫射光学层析成像中使用的建模技术进行了全面的概述。
Diffuse optical tomography, also known as near infrared tomography, has been under investigation, for non-invasive functional imaging of tissue, specifically for the detection and characterization of breast cancer or other soft tissue lesions. Much work has been carried out for accurate modeling and image reconstruction from clinical data. NIRFAST, a modeling and image reconstruction package has been developed, which is capable of single wavelength and multi-wavelength optical or functional imaging from measured data. The theory behind the modeling techniques as well as the image reconstruction algorithms is presented here, and 2D and 3D examples are presented to demonstrate its capabilities. The results show that 3D modeling can be combined with measured data from multiple wavelengths to reconstruct chromophore concentrations within the tissue. Additionally it is possible to recover scattering spectra, resulting from the dominant Mie-type scatter present in tissue. Overall, this paper gives a comprehensive over view of the modeling techniques used in diffuse optical tomographic imaging, in the context of NIRFAST software package.
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