Repetetive hindlimb movement using intermittent adaptive neuromuscular electrical stimulation in an incomplete spinal cord injury rodent model.
Repetetive hindlimb movement using intermittent adaptive neuromuscular electrical stimulation in an incomplete spinal cord injury rodent model.
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DOI：
10.1016/j.expneurol.2010.02.011
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发表时间：
2010-06
影响因子：
5.3
通讯作者：
Jung, Ranu
中科院分区：
文献类型：
--
作者：
Fairchild, Mallika D.;Kim, Seung-Jae;Iarkov, Alex;Abbas, James J.;Jung, Ranu
关键词：
这项工作的长期目标是了解基于电刺激的运动疗法可以利用神经可塑性来加速和增强不完全脊髓损伤（iSCI）后的感觉运动恢复的机制。在具有胸部挫伤的成年Long Evans大鼠（T8椎骨水平，155± 2Kdyne）中实施适应性神经肌肉电刺激（aNMES）范例。在使用轻度麻醉的动物的长时间会话中，使用aNMES控制系统刺激髋屈肌和伸肌，以产生期望的髋关节运动。使用模式发生器/模式整形器结构的aNMES控制系统调节脉冲幅度以调制肌肉力，从而控制臀部运动。使用间歇刺激范例（5个循环/组;组之间休息20秒; 100组）。在每个周期中，髋关节旋转导致足部足底表面接触固定刷子，用于适当定时的皮肤输入。在动物从损伤中恢复的几天内重复训练。结果表明，aNMES自动可靠地跟踪所需的髋关节轨迹，误差较低，并在长时间训练期间仅逐渐增加刺激即可维持运动范围。因此，间歇性aNMES解释了可以影响对NMES的响应的许多因素：电极稳定性、脊髓神经回路的兴奋性、非线性肌肉募集、疲劳、由于皮肤输入引起的脊髓反射和动物的内源性恢复。因此，在iSCI啮齿动物模型中的这种新型aNMES应用可以用于慢性刺激研究，以研究基于NMES的重复运动疗法靶向的神经可塑性机制。
The long-term objective of this work is to understand the mechanisms by which electrical stimulation based movement therapies may harness neural plasticity to accelerate and enhance sensorimotor recovery after incomplete spinal cord injury (iSCI). An adaptive neuromuscular electrical stimulation (aNMES) paradigm was implemented in adult Long Evans rats with thoracic contusion injury (T8 vertebral level, 155±2 Kdyne). In lengthy sessions with lightly anesthetized animals, hip flexor and extensor muscles were stimulated using an aNMES control system in order to generate desired hip movements. The aNMES control system, which used a pattern generator/pattern shaper structure, adjusted pulse amplitude to modulate muscle force in order to control hip movement. An intermittent stimulation paradigm was used (5-cycles/set; 20-second rest between sets; 100 sets). In each cycle, hip rotation caused the foot plantar surface to contact a stationary brush for appropriately timed cutaneous input. Sessions were repeated over several days while the animals recovered from injury. Results indicated that aNMES automatically and reliably tracked the desired hip trajectory with low error and maintained range of motion with only gradual increase in stimulation during the long sessions. Intermittent aNMES thus accounted for the numerous factors that can influence the response to NMES: electrode stability, excitability of spinal neural circuitry, non-linear muscle recruitment, fatigue, spinal reflexes due to cutaneous input, and the endogenous recovery of the animals. This novel aNMES application in the iSCI rodent model can thus be used in chronic stimulation studies to investigate the mechanisms of neuroplasticity targeted by NMES-based repetitive movement therapy.
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影响因子：
4.6
作者：
ABBAS, JJ;CHIZECK, HJ
通讯作者：
CHIZECK, HJ
影响因子：
3.2
作者：
Behrman, Andrea L.;Bowden, Mark G.;Nair, Preeti M.
通讯作者：
Nair, Preeti M.
影响因子：
3
作者：
Ichihara, Kazuhiko;Venkatasubramanian, Ganapriya;Abbas, James J.;Jung, Ranu
通讯作者：
Jung, Ranu
DOI：
10.1109/tbme.2008.2008193
发表时间：
2009-02
期刊：
IEEE transactions on bio-medical engineering
影响因子：
--
作者：
Kim SJ;Fairchild MD;Iarkov Yarkov A;Abbas JJ;Jung R
通讯作者：
Jung R
影响因子：
4.3
作者：
Field-Fote, EC
通讯作者：
Field-Fote, EC