Light and circadian regulation of clock components aids flexible responses to environmental signals.
Light and circadian regulation of clock components aids flexible responses to environmental signals.
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DOI：
10.1111/nph.12853
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发表时间：
2014-07
期刊：
影响因子：
--
通讯作者：
Millar AJ
中科院分区：
文献类型：
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作者：
Dixon LE;Hodge SK;van Ooijen G;Troein C;Akman OE;Millar AJ
生物钟以24小时为周期测量时间，通过将生物过程调整到一天中最合适的时间来增强健康。时钟的连锁反馈环机制在物种间是守恒的；然而，循环的数量是不同的。数学和计算分析表明，回路复杂性影响振荡器的整体灵活性，包括其对夹带信号的响应。我们在不同的光周期之间使用了一种判别性的实验方法，以便在最小的昼夜节律网络（在金黄色葡萄球菌中）和更复杂的网络（在拟南芥中）中测试这一建议。金牛的转录和翻译报告主要跟踪黎明或黄昏，而拟南芥的反应范围更广，与其更灵活的时钟一致。模型分析支持在更复杂的网络的组成部分之间的这种响应多样性的需求。然而，这些和早期的数据表明，O. tauri网络保持着惊人的灵活性，尽管它的电路很简单。我们发现，从实验数据构建的模型可以从多个环路和/或多个光输入中显示出灵活性。我们的研究结果表明，牛头牛采用了后一种策略，可能是基因组减少的结果。
The circadian clock measures time across a 24 h period, increasing fitness by phasing biological processes to the most appropriate time of day. The interlocking feedback loop mechanism of the clock is conserved across species; however, the number of loops varies. Mathematical and computational analyses have suggested that loop complexity affects the overall flexibility of the oscillator, including its responses to entrainment signals. We used a discriminating experimental assay, at the transition between different photoperiods, in order to test this proposal in a minimal circadian network (in Ostreococcus tauri) and a more complex network (in Arabidopsis thaliana). Transcriptional and translational reporters in O. tauri primarily tracked dawn or dusk, whereas in A. thaliana, a wider range of responses were observed, consistent with its more flexible clock. Model analysis supported the requirement for this diversity of responses among the components of the more complex network. However, these and earlier data showed that the O. tauri network retains surprising flexibility, despite its simple circuit. We found that models constructed from experimental data can show flexibility either from multiple loops and/or from multiple light inputs. Our results suggest that O. tauri has adopted the latter strategy, possibly as a consequence of genomic reduction.
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影响因子：
2.9
作者：
Djouani-Tahri, El Batoul;Motta, Jean-Paul;Corellou, Florence
通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
9.9
作者：
通讯作者：
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