Associations of Dietary Intake with Urinary Melamine and Derivative Concentrations among Children in the GAPPS Cohort.
Associations of Dietary Intake with Urinary Melamine and Derivative Concentrations among Children in the GAPPS Cohort.
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DOI：
10.3390/ijerph19094964
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发表时间：
2022-04-19
影响因子：
--
通讯作者：
Sathyanarayana, Sheela
中科院分区：
文献类型：
--
作者：
Melough, Melissa M.;Day, Drew B.;Fretts, Amanda M.;Wang, Sarah;Flynn, Joseph T.;de Boer, Ian H.;Zhu, Hongkai;Kannan, Kurunthachalam;Sathyanarayana, Sheela
三聚氰胺是一种肾毒性工业化学品。饮食是三聚氰胺暴露的一个来源，但很少有研究研究主要的饮食贡献因素，特别是在儿童中。我们评估了全球预防早产和死产队列中123名4-6岁儿童的饮食与尿三聚氰胺及其衍生物浓度的关系。收集尿液前一天的儿童饮食采用24小时饮食回忆法进行评估。通过多元线性回归分析肉类、水果和谷物摄入量与三聚氰胺暴露的关系。在二次分析中对剩余的食物组进行了检查。三聚氰胺、三聚氰胺和三聚氰酸的平均浓度分别为6.1(12.4)、1.9(2.1)和6 0.6(221.2)ng/m L。红肉消费者的三聚氰胺暴露比非消费者高98%(95%可信区间：15%，241%)，但最高的消费者没有增加三聚氰胺暴露。某些水果的摄入量越多，尿白蛋白含量越低。最大的酸奶消费者比非消费者暴露的三聚氰胺高112%(95%可信区间：29%，247%)。食用不含土豆的淀粉类蔬菜与尿白蛋白增加139%(95%可信区间：6%，437%)相关。这些观察到的关联应该在未来的研究中得到证实，使用更大的样本并加强对非饮食暴露途径的监测。
Melamine is a nephrotoxic industrial chemical. Diet is one source of melamine exposure, yet little work has examined the main dietary contributors, particularly among children. We evaluated associations of diet with urinary melamine and derivative concentrations among 123 children aged 4–6 years in the Global Alliance to Prevent Prematurity and Stillbirth cohort. Children’s diets on the day preceding urine collection were assessed using 24-h dietary recalls. Associations of meat, fruit, and grain intakes with melamine exposure were examined using multiple linear regression. Remaining food groups were examined in secondary analyses. Mean (SD) melamine, ammelide, and cyanuric acid concentrations were 6.1 (12.4), 1.9 (2.1), and 60.6 (221.2) ng/mL, respectively. The second tertile of red meat consumers had 98% (95% CI: 15%, 241%) greater melamine exposure than non-consumers, yet the highest consumers did not have increased exposure. Greater consumption of certain fruits was associated with lower urinary ammelide. The top yogurt consumers had 112% (95% CI: 29%, 247%) greater melamine exposure than non-consumers. Consumption of starchy vegetables excluding potatoes was associated with 139% (95% CI: 6%, 437%) greater urinary ammelide. These observed associations should be confirmed in future studies using larger samples and increased monitoring of non-dietary routes of exposure.
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影响因子：
5
作者：
Lam, Ching-Wan;Lan, Lawrence;Tam, Paul Kwong-Hang
通讯作者：
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影响因子：
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DOI：
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发表时间：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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