Proteobacteria: A Common Factor in Human Diseases.

Proteobacteria: A Common Factor in Human Diseases.
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DOI:
10.1155/2017/9351507
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发表时间:
2017
影响因子:
--
通讯作者:
Gasbarrini A
Gasbarrini A
中科院分区:
生物学3区
文献类型:
--
作者:
Rizzatti G;Lopetuso LR;Gibiino G;Binda C;Gasbarrini A

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微生物群代表肠道宿主中存在的整个微生物群落。它有几个功能,与宿主建立互惠关系。近年来,关注这一主题的研究数量激增,特别是肠道疾病。在这种情况下,变形菌是最丰富的门之一,包括几种已知的人类病原体。本文综述了变形菌不仅在肠道疾病中,而且在肠道外疾病中的作用的最新发现。事实上,越来越多的数据将变形菌门确定为疾病的可能微生物特征。几项研究表明,在这种条件下,属于这一门的成员数量增加。目前的主要证据涉及代谢紊乱和炎症性肠病。然而,最近的研究表明,在肺部疾病,如哮喘和慢性阻塞性肺病中也有作用,但证据仍然很少。值得注意的是,所有这些病症都由不同程度的炎症维持,因此这代表了变形杆菌相关疾病的核心方面。
Microbiota represents the entire microbial community present in the gut host. It serves several functions establishing a mutualistic relation with the host. Latest years have seen a burst in the number of studies focusing on this topic, in particular on intestinal diseases. In this scenario, Proteobacteria are one of the most abundant phyla, comprising several known human pathogens. This review highlights the latest findings on the role of Proteobacteria not only in intestinal but also in extraintestinal diseases. Indeed, an increasing amount of data identifies Proteobacteria as a possible microbial signature of disease. Several studies demonstrate an increased abundance of members belonging to this phylum in such conditions. Major evidences currently involve metabolic disorders and inflammatory bowel disease. However, more recent studies suggest a role also in lung diseases, such as asthma and chronic obstructive pulmonary disease, but evidences are still scant. Notably, all these conditions are sustained by various degree of inflammation, which thus represents a core aspect of Proteobacteria-related diseases.
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