Functional connectivity in the resting-state motor networks influences the kinematic processes during motor sequence learning.
Functional connectivity in the resting-state motor networks influences the kinematic processes during motor sequence learning.
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DOI：
10.1111/ejn.12755
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发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Bove M
中科院分区：
文献类型：
--
作者：
Bonzano L;Palmaro E;Teodorescu R;Fleysher L;Inglese M;Bove M
神经影像学研究支持小脑皮质和纹状体皮质运动回路参与运动序列学习。在这里，我们研究了运动序列学习的增益是否可以依赖于先验的静息状态功能连接（rsFC）之间的运动区域和结构属于这些电路。14名健康受试者进行了静息状态fMRI会话。之后，他们被要求尽可能快和准确地再现一系列的手指反向运动。所有受试者都通过减少触摸持续时间和/或敲击间隔来增加他们的运动速率。rsFC分析显示，静息时左右M1和左右辅助运动皮层（SMA）主要与其他运动区相连。考虑到不同运动学参数的协变量分析表明，运动速率增加更大的受试者是左侧M1和SMA与小脑右侧小叶VIII的rsFC更强的受试者。值得注意的是，叩击间隔缩短越大的受试者，左侧M1和SMA的rsFC与丘脑的联合核团越强。相反，右侧M1和SMA种子的回归分析显示，对于不位于小脑和丘脑的不同协变量，只有少数显著聚类。在右侧M1和SMA之间未发现共同簇。所有这些发现都表明，负责运动学习改善的神经回路在休息时存在重要的功能连接，涉及与直接控制手指运动的半球、丘脑和小脑相关的运动区域。
Neuroimaging studies support the involvement of the cerebello-cortical and striato-cortical motor loops in motor sequence learning. Here, we investigated whether the gain of motor sequence learning could depend on a priori resting-state functional connectivity (rsFC) between motor areas and structures belonging to these circuits. Fourteen healthy subjects underwent a resting-state fMRI session. Afterward, they were asked to reproduce a verbally-learned sequence of finger opposition movements as fast and accurate as possible. All subjects increased their movement rate with practice, by reducing touch duration and/or inter tapping interval. The rsFC analysis showed that at rest left and right M1 and left and right supplementary motor cortex (SMA) were mainly connected with other motor areas. The covariate analysis taking into account the different kinematic parameters indicated that the subjects achieving greater movement rate increase were those showing stronger rsFC of the left M1 and SMA with the right lobule VIII of the cerebellum. Notably, the subjects with greater inter tapping interval reduction showed stronger rsFC of the left M1 and SMA with the association nuclei of the thalamus. Conversely, the regression analysis with the right M1 and SMA seeds showed only few significant clusters for the different covariates not located in the cerebellum and thalamus. No common clusters were found between right M1 and SMA. All these findings indicate important functional connections at rest of those neural circuits responsible of motor learning improvement, involving the motor areas related to the hemisphere directly controlling the finger movements, the thalamus and the cerebellum.
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DOI：
10.1016/j.cub.2009.04.028
发表时间：
2009-06-23
期刊：
Current biology : CB
影响因子：
--
作者：
Albert NB;Robertson EM;Miall RC
通讯作者：
Miall RC
影响因子：
5.7
作者：
Bonzano, Laura;Tacchino, Andrea;Bove, Marco
通讯作者：
Bove, Marco
影响因子：
2.5
作者：
AERTSEN, AMHJ;GERSTEIN, GL;PALM, G
通讯作者：
PALM, G
影响因子：
3
作者：
Langan J;Peltier SJ;Bo J;Fling BW;Welsh RC;Seidler RD
通讯作者：
Seidler RD
影响因子：
5.7
作者：
Lowe, MJ;Dzemidzic, M;Phillips, MD
通讯作者：
Phillips, MD